Fosmidomycin

Fosmidomycin Struktur
66508-53-0
CAS-Nr.
66508-53-0
Englisch Name:
Fosmidomycin
Synonyma:
Antibiotic FR-31705;10 Mg, 50 Mg, 100 Mg, 1g;Fosmidomycin sodium salt hydrate;3-Phosphono 1-(N-formylhydroxyamino)propane;3-(Formylhydroxyamino)propylphosphonic acid;(3-(N-hydroxyforMaMido)propyl)phosphonic acid;Phosphonic acid, P-[3-(formylhydroxyamino)propyl]-;(3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt
CBNumber:
CB31178815
Summenformel:
C4H10NO5P
Molgewicht:
183.1
MOL-Datei:
66508-53-0.mol

Fosmidomycin Eigenschaften

Schmelzpunkt:
158-160° (dec); mp 160-166° (dec) (Hemmi)
storage temp. 
-20°C
Löslichkeit
H2O: soluble20mg/mL, clear
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

WGK Germany  3
Toxizität LD50 in mice and rats (mg/kg): >11000 orally; ~8000 s.c. (Wiesner, 2003)

Fosmidomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Fosmidomycin sodium salt hydrate has been used as an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase in a study to determine monotropin carvacrol biosynthesis in Satureja khuzistanica plant.

Definition

ChEBI: Propylphosphonic acid in which one of the hydrogens at position 3 is substituted by a formyl(hydroxy)amino group. An antibiotic obtained from Streptomyces lavendulae, it specifically inhibits DXP reductoisomerase (EC 1.1.1.267), a key enzyme i the non-mevalonate pathway of isoprenoid biosynthesis.

Biochem/physiol Actions

Fosmidomycin is an inhibitor of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) (MEP synthase): an antimalarial compound. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway).

Fosmidomycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fosmidomycin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 5)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14059 65
Guangzhou Isun Pharmaceutical Co., Ltd 020-39119399 18927568969
isunpharm@qq.com China 4428 55
Suzhou Vosun Biotech Co.,Ltd 0512-66569378-8002 66569378
info@vosunchemical.com China 614 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822
czbjpharma@126.com China 18488 58

  • 3-(Formylhydroxyamino)propylphosphonic acid
  • 3-Phosphono 1-(N-formylhydroxyamino)propane
  • Antibiotic FR-31705
  • 10 Mg, 50 Mg, 100 Mg, 1g
  • (3-(N-hydroxyforMaMido)propyl)phosphonic acid
  • (3-(N-Hydroxyformamido)propyl)phosphonic acid sodium salt
  • Fosmidomycin sodium salt hydrate
  • Phosphonic acid, P-[3-(formylhydroxyamino)propyl]-
  • 66508-53-0
Copyright 2019 © ChemicalBook. All rights reserved