enniatin A1

enniatin A1 Struktur
4530-21-6
CAS-Nr.
4530-21-6
Englisch Name:
enniatin A1
Synonyma:
enniatin A1;2-(N-Methyl-L-valine)enniatin A;(3S,6R,9S,12R,15S,18R)-3,9-bis[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,15,18-tetra(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone;Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]
CBNumber:
CB32079106
Summenformel:
C35H61N3O9
Molgewicht:
667.879
MOL-Datei:
4530-21-6.mol

enniatin A1 Eigenschaften

Schmelzpunkt:
116-117 °C
Siedepunkt:
840.5±65.0 °C(Predicted)
Dichte
1.027±0.06 g/cm3(Predicted)
storage temp. 
-20°C
Löslichkeit
DMSO: soluble10mg/mL
Aggregatzustand
White to off-white crystalline solid.
pka
-1.44±0.70(Predicted)

Sicherheit

Kennzeichnung gefährlicher T
R-Sätze: 23/24/25
S-Sätze: 45
RIDADR  2811
WGK Germany  3
HazardClass  6.1(a)
PackingGroup  I

enniatin A1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Enniatins are a family of depsipeptide ionophores, produced several Fusarium species. More recently, the effects of the ennitins on acyl-CoA cholesterol transferase, transporters and the selectivity of their antitumour action have received more focus. Enniatin A1 is one of four major analogues of the enniatin complex and has previously not been available for investigation.

Definition

ChEBI: An enniatin obtained from formal cyclocondensation of one N-[(2R)-2-hydroxy-3-methylbutanoyl]-N-methyl-L-valine and two N-[(2R)-2-hydroxy-3-methylbu anoyl]-N-methyl-L-isoleucine units.

Biochem/physiol Actions

Enniatins are a group of cyclohexadepsipeptide mycotoxins produced by Gnomonia errabuda and several Fusaria species, with phytotoxic, antibiotic, and insecticidal activities. Enniatins function as ionophors by their incorporation into the cellular membrane to form dimeric structures that transport monovalent ions across the membrane (especially the mitochondrial membranes) affecting oxidative phosphorylation uncoupling. It has been demonstrated that enniatins have a cytotoxic effect on human cancer cells. Furthermore, incubation of H4IIE hepatoma cells with enniatins strongly diminished phosphorylation of the ERK (p44/p42).

enniatin A1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


enniatin A1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 57)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32480 60
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
BOC Sciences
+16314854226
inquiry@bocsci.com United States 19743 58
Aladdin Scientific
+1-833-552-7181
sales@aladdinsci.com United States 52927 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 13675144456
sean.lv@synzest.com China 11442 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223
psaitong@jm-bio.com China 29834 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
info@efebio.com China 9709 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
psaitong@jm-bio.com China 12308 58
Lynnchem 86-(0)29-85992781 17792393971
info@lynnchem.com China 4587 58

4530-21-6()Verwandte Suche:


  • Cyclo[(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-isoleucyl-(2R)-2-hydroxy-3-methylbutanoyl-N-methyl-L-valyl]
  • enniatin A1
  • 2-(N-Methyl-L-valine)enniatin A
  • (3S,6R,9S,12R,15S,18R)-3,9-bis[(2S)-butan-2-yl]-4,10,16-trimethyl-6,12,15,18-tetra(propan-2-yl)-1,7,13-trioxa-4,10,16-triazacyclooctadecane-2,5,8,11,14,17-hexone
  • 4530-21-6
  • C35H61N3O9
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