SI-2

SI-2 Struktur
380537-35-9
CAS-Nr.
380537-35-9
Englisch Name:
SI-2
Synonyma:
SI-2;(E)-SI-2;(E)SI2,(E) SI 2;1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-;Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
CBNumber:
CB33152741
Summenformel:
C15H15N5
Molgewicht:
265.313
MOL-Datei:
380537-35-9.mol

SI-2 Eigenschaften

Siedepunkt:
459.9±37.0 °C(Predicted)
Dichte
1.22±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
Soluble in DMSO (up to 20 mg/ml).
pka
11.05±0.70(Predicted)
Aggregatzustand
solid
Farbe
Pale orange
Stabilität:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

SI-2 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SI-2 is an inhibitor of steroid receptor coactivator-3 (SRC-3). Induces cell death in verious breast cancer cells.

Biochem/physiol Actions

SI-2 targets the receptor-interacting domain (RID) of steroid receptor coactivators (SRCs) and suppresses cellular transcriptional activity (Effec. conc. >/= 5 nM in cell-based SRC-1, SRC-2, and SRC-3 reporter assays) by downregulating SRCs protein, but not transcript level (Effec. conc. >/= 12.5 nM against SRC-3, >/= 25 nM against SRC-1 and SCR-2 in MDA-MB-468 culture). SI-2 is cytotoxic to breast cancer cultures (IC50?= 1.5 nM/BT-474, 3.4 nM/MDA-MB-468, 22 nM/MCF-7), but not to normal hepatocytes even at 500 nM concentration. SI-2 is reported to be orally available in mice and, when administered intraperitoneally (2 mg/kg b.i.d.), effectively suppress MDA-MB-468-derived tumor expansion in mice?in vivowith good pharmacokinetics (Cmax?= 30 μM,?tmax?= 0.25 h,?t1/2?= 1.0 h; 20 mg/kg i.p.) and no apparent adverse effects to the animals.

SI-2 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


SI-2 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30250 58
TargetMol Chemicals Inc.
+1-781-999-5354
support@targetmol.com United States 19973 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Shanghai Hongye Biotechnology Co. Ltd 400-9205774
sales@glpbio.cn China 6870 58
DC Chemicals 021-58447131 13564518121
sales@dcchemicals.com China 9412 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
sales@chemegen.com China 11289 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
order@med-bio.cn China 8141 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44941 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 23980 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939
shenlinxing@macklin.cn China 29802 58

380537-35-9()Verwandte Suche:


  • SI-2
  • Ethanone, 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
  • 1-(2-pyridinyl)-, 2-(1-methyl-1H-benzimidazol-2-yl)hydrazone, (1E)-
  • (E)-SI-2
  • (E)SI2,(E) SI 2
  • 380537-35-9
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