ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

307519-88-6

CAS-Nr.: 307519-88-6

Englisch Name:: ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate

Synonyma:: NMDI14;NMDI14 >=97% (HPLC);inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14;ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate;3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester

CBNumber:: CB33589260

Summenformel:: C21H25N3O4S

Molgewicht:: 415.51

MOL-Datei:: 307519-88-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 23

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Eigenschaften

Siedepunkt:: 658.8±55.0 °C(Predicted)

Dichte: 1.250±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO : ≥ 25 mg/mL (60.17 mM)

pka: 13.42±0.40(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

NMDI14 has been used as a nonsense-mediated mRNA decay (NMD) inhibitor:

to study its effects on differentiating cardiomyocytes
to study its effects on zebrafish pdzk1 gene-knockout embryos
to analyze its effects on the apoptosis of colorectal cancer cells

Biochem/physiol Actions

NMDI14 is a potent nonsense-mediated RNA decay (NMD) inhibitor. NMDI14 targets a pocket in the SMG7 protein and disrupts SMG7–UPF1 interactions. NMDI14 restores of full-length p53 protein activity in in cells with premature termination codons (PTC) mutated p53.

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 23)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Zhengzhou HSH Science & Technology Co., Ltd.	0371-55932928 18937192232	1282296214@qq.com	China	496	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Guangzhou Zhiya Chemdrugs Co.,Ltd	18122150900	sculk28@163.com	China	647	55
ShangHai Biochempartner Co.,Ltd	17754423994 17754423994	2853530910@QQ.com	China	8018	62
Twochem Co.Ltd.	021-58111628 15800915896		China	1988	58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.	18081075745	chemflowtech@sina.com	China	1886	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai hongqu biomedical technology co. LTD	88888888888	hongquchem@qq.com	China	5132	58

ethyl 2-(2-(6,7-dimethyl-3-oxo-1,2,3,4-tetrahydroquinoxalin-2-yl)acetamido)-4,5-dimethylthiophene-3-carboxylate
NMDI14
3-Thiophenecarboxylic acid, 4,5-dimethyl-2-[[2-(1,2,3,4-tetrahydro-6,7-dimethyl-3-oxo-2-quinoxalinyl)acetyl]amino]-, ethyl ester
NMDI14 >=97% (HPLC)
inhibit,Inhibitor,NMDI14,NMDI-14,NMDI 14
307519-88-6