γ-Secretase Inhibitor I - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A potent, cell-permeable, reversible γ-secretase inhibitor that preferentially appears to inhibit the secretion of Aβ
1-40 (>90%) over Aβ
1-42 (~15%). Aβ
total IC
50 ~ 15 M; Aβ
1-40 IC
50 ~ 22 M; Aβ
1-42 IC
50 >50 M in CHO cells stable transfected with the cDNA encoding βAPP695.
Biochem/physiol Actions
Primary Targetsecretion of Aβ
γ-Secretase Inhibitor I - Calbiochem Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte