Diisopropyl 2,2-dihydroxymalonate Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
As demonstrated by
Laszlo Kürti′s lab, the sterically hindered di-isopropyl keto malonate hydrate (and
902594) are excellent
N-umpolung reagents for both aliphatic and aromatic primary amines via a simple condensation reaction. The steric hindrance in ester moiety allows the preparation of the corresponding iminomalonates in high yield and lends these imines sufficient hydrolytic stability during the purification process. The
N-alkyl as well as
N-aryl iminomalonates act as singly N-electrophilic reagents towards strong C-nucleophiles such as alkyl- and arylmetals (e.g., Grignard reagents). Thus, unsymmetrical secondary amines may be readily preapred at low temperatures and in the absence of transition metal catalysts.
Diisopropyl 2,2-dihydroxymalonate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
