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1-(5-Nitro-2-thiazolyl)-2-imidazolidinon

niridazole Struktur
61-57-4
CAS-Nr.
61-57-4
Bezeichnung:
1-(5-Nitro-2-thiazolyl)-2-imidazolidinon
Englisch Name:
niridazole
Synonyma:
BA32644;Ambilhar;niridazole;NSC-136947;Nitrothiamidazole;1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE;1-(5-nitrothiazol-2-yl)imidazolidin-2-one;2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-;1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
CBNumber:
CB3896840
Summenformel:
C6H6N4O3S
Molgewicht:
214.204
MOL-Datei:
61-57-4.mol
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1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Eigenschaften

Schmelzpunkt:
260-262°
Dichte
1.561 (estimate)
Brechungsindex
1.6200 (estimate)
Aggregatzustand
solid
pka
12.73±0.20(Predicted)
Farbe
Yellow crystals from DMF/MeOH
Wasserlöslichkeit
0.13g/L(25 ºC)
IARC
2B (Vol. 13, Sup 7) 1987
EPA chemische Informationen
Niridazole (61-57-4)

Sicherheit

Giftige Stoffe Daten 61-57-4(Hazardous Substances Data)
Toxizität TDLo orl-rat: 8 g/kg/90W-I:NEO CALEDQ 4,305,78 orl-rat LD50:900 mg/kg FAZMAE 17,108,73

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Antischistosomal.

Pharmakologie

Niridazole exhibits schistosomicide and amebicidal action. The mechanism of action is not known. It seems likely that it is concentrated in the parasite organism, which causes inhibition of phosphorylase activation, which is expressed in the depletion of glycogen reserves.
It also may inhibit spermatogenesis of parasites by affecting the production of eggs. It is used for diseases caused by Dracunculus meddinesis, as well as Shistosoma haematobium and Shistosoma mansoni. It belongs to a group of tertiary drugs and is used only in the absence of the drug of choice. Synonyms of this drug are ambilhar and others.

Sicherheitsprofil

Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intraperitoneal route. Moderately toxic by ingestion. Experimental reproductive effects. Human mutation data reported. Used as an amoebicide and schistosomicidal agent.

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1-(5-Nitro-2-thiazolyl)-2-imidazolidinon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 9)Lieferanten
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Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21691 55
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Alfa Chemistry 1-516-6625404
support@alfa-chemistry.com United States 9171 60
TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24131 58

61-57-4(1-(5-Nitro-2-thiazolyl)-2-imidazolidinon)Verwandte Suche:

5-Nitrothiazol-2-ylamin 1-(5-Nitro-2-thiazolyl)-2-imidazolidinon
  • niridazole
  • Ambilhar
  • BA32644
  • Nitrothiamidazole
  • NSC-136947
  • 1-(5-nitrothiazol-2-yl)imidazolidin-2-one
  • 1-(5-NITRO-2-THIAZOLYL)-2-IMIDAZOLIDINONE
  • 1-(5-nitro-1,3-thiazol-2-yl)imidazolidin-2-one
  • 2-Imidazolidinone, 1-(5-nitro-2-thiazolyl)-
  • 61-57-4
  • C6H6N4O3S
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