Platencin Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Platencin is a natural, broad spectrum Gram-
positive antibiotic isolated from
S. platensis, which is also the source of platensimycin . Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-
ketoacyl-
ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF. The IC
50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively. It does not exhibit cross-
resistance to antibiotic resistant bacterial strains, including methicillin-
resistant
S. aureus, vancomycin-
intermediate
S. aureus, and vancomycin-
resistant
Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.
Verwenden
Platencin is a novel, broad spectrum, Gram-positive antibiotic produced by strains of Streptomyces platensis. Platencin is more potent than its analogue, platensimycin. Platencin shows potent in vivo efficacy without any observed toxicity. Platencin targets two essential proteins, b-ketoacyl-acyl carrier protein (ACP) synthase II (FabF) and III (FabH) whereas platensimycin targets only FabF.
Enzyminhibitor
This antibiotic (FW = 425.2 g/mol; CAS 869898-86-2; Soluble in ethanol, methanol, DMF or DMSO) inhibits both Staphylococcus aureus b-ketoacyl- [acyl-carrier-protein] synthases II and III, with IC50 values of 1.95 and 3.91 μg/mL, respectively. Platencin exhibits strong, broad-spectrum, Grampositive antibacterial activity to key antibiotic resistant strains, including methicillin-resistant Staphylococcus aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococcus faecium, without evidence of toxicity in humans.
Platencin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
