4-Epioxytetracycline

4-Epioxytetracycline Struktur
14206-58-7
CAS-Nr.
14206-58-7
Englisch Name:
4-Epioxytetracycline
Synonyma:
4-EPIOXYTETRACYCLINE;Oxytetracycline IMpurity A;[4R-(4α,4aβ,5β,5aβ,6α,12aβ]-;Oxytetracycline EP Impurity A;4-Epi-Oxytetracycline, EvoPure;Oxytetracycline Hydrochloride EP Impurity A;4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY ST;Oxytetracycline EP Impurity A/4-epi-Oxytetracycline;Oxytetracycline Impurity 1(Oxytetracycline EP Impurity A);4-Epioxytetracycline,97%,'can be used as secondary standard'
CBNumber:
CB4500795
Summenformel:
C22H24N2O9
Molgewicht:
460.43
MOL-Datei:
14206-58-7.mol

4-Epioxytetracycline Eigenschaften

Schmelzpunkt:
168°C
Siedepunkt:
839.6±65.0 °C(Predicted)
Dichte
1.71±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
Löslichkeit
DMSO: slightly soluble; Methanol: slightly, heated
pka
4.50±1.00(Predicted)
Aggregatzustand
Powder
Farbe
Greenish-beige to brownish
Stabilität:
Hygroscopic, Light Sensitive, Unstable in Solution
EPA chemische Informationen
2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6S,12aS)- (14206-58-7)
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  29413020
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H361 Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. Reproduktionstoxizität Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P337+P313 Bei anhaltender Augenreizung: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Behälter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

4-Epioxytetracycline Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Epioxytetracycline is a metabolite of Oxytetracycline. It has been found in swine manure compost and wastewater and is considered a pollutant. This highly pure metabolite can be used as a secondary reference standard during stability studies of oxytetracycline. It can also be used to study the degradation pathway and products of tetracyclines.

Chemische Eigenschaften

greenish-beige to brownish powder

Mode of action

Oxytetracycline causes inhibition of protein synthesis. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome.
In an acellular model system of protein synthesis using ribosomes from tetracycline-sensitive and resistant strains of E. coli in the synthesis of polyphenylalanine, Oxytetracycline showed inhibitory activity along with minocycline. 4-Epioxytetracycline and beta-apo-oxytetracycline had competing properties with respect to oxytetracycline at the stage of penetration through the cell membrane but did not, however, suppress the synthesis of polyphenylalanine.

Einzelnachweise

1] I V BELIAVSKAIA. [Study of the mechanism of action of minocycline and of certain other tetracycline group compounds].[J]. Antibiotiki, 1976, 21 3: 242-245.
[2] BENT HALLING-S?RENSEN J. T G Sengel?v. Toxicity of Tetracyclines and Tetracycline Degradation Products to Environmentally Relevant Bacteria, Including Selected Tetracycline-Resistant Bacteria[J]. Archives of Environmental Contamination and Toxicology, 2002, 42 1: 263-271. DOI:10.1007/s00244-001-0017-2.
[3] ANNE KRUSE LYKKEBERG . Quantitative analysis of oxytetracycline and its impurities by LC-MS-MS[J]. Journal of pharmaceutical and biomedical analysis, 2004, 34 2: Pages 325-332. DOI:10.1016/S0731-7085(03)00500-4.
[4] RICHENG XUAN. Hydrolysis and photolysis of oxytetracycline in aqueous solution.[J]. Journal of Environmental Science and Health Part B-pesticides Food Contaminants and Agricultural Wastes, 2010, 45 1: 73-81. DOI:10.1080/03601230903404556.
[5] HONGXING HAN. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats[J]. Scientific Reports, 2016, 6 1. DOI:10.1038/srep23141.

4-Epioxytetracycline Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-Epioxytetracycline Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 64)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 853 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28180 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14335 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29823 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 8232 58
BOC Sciences
16314854226; +16314854226
inquiry@bocsci.com United States 19743 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9923 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11927 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
Guangzhou PI PI Biotech Inc 020-81716320 +86-13602409664
Sales@pipitech.com China 3635 55

14206-58-7()Verwandte Suche:


  • 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97
  • 4-Epioxytetracycline, 'can be used as secondary standard', 97%
  • 4-Epioxytetracycline,97%,'can be used as secondary standard'
  • 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY ST
  • [4R-(4α,4aβ,5β,5aβ,6α,12aβ]-
  • Oxytetracycline IMpurity A
  • 4-EPIOXYTETRACYCLINE
  • Oxytetracycline EP Impurity A/4-epi-Oxytetracycline
  • (4R,4aR,5S,5aR,6S,12aR)-4-(dimethylamino)-1,5,6,10,11,12a-hexahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
  • Oxytetracycline EP Impurity A
  • Oxytetracycline Impurity 1(Oxytetracycline EP Impurity A)
  • 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-, (4R,4aR,5S,5aR,6S,12aS)-
  • 4-EPIOXYTETRACYCLINE, 'CAN BE USED AS SECONDARY STANDARD', 97 USP/EP/BP
  • Oxytetracycline Hydrochloride EP Impurity A
  • (4R,4aR,5S,5aR,6S,12aS)-4-(dimethylamino)-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide(4-epioxytetracycline),
  • 4-Epi-Oxytetracycline, EvoPure
  • 14206-58-7
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Amines
  • Chiral Reagents
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