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Manidipine

Manidipine Struktur
89226-50-6
CAS-Nr.
89226-50-6
Englisch Name:
Manidipine
Synonyma:
Artedil;Iperten;Manidipine;Franidipine;Manidipine 6300;Manidipine（base）;Manidipine(CV-4093);Manidipine (Manyper);Manidipine Impurity1254;Manidipine (10mM in DMSO)
CBNumber:
CB4506757
Summenformel:
C35H38N4O6
Molgewicht:
610.7
MOL-Datei:
89226-50-6.mol
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Manidipine Eigenschaften

Schmelzpunkt:
125-128°C
Siedepunkt:
722.0±60.0 °C(Predicted)
Dichte
1.232±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
Löslichkeit
Soluble in DMSO > 10 mM
Aggregatzustand
Powder
pka
6.12±0.10(Predicted)
LogP
4.135
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Manidipine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Manidipine is a dihydropyridine L- and T-type calcium channel blocker. It blocks recombinant rabbit L-type (α1Cα2/δβ1a) and human T-type (α1H) calcium channels expressed in Xenopus oocytes and native L-type channels in dissociated guinea pig cardiac ventricular cells (IC50 = 2.6 nM). Manidipine inhibits intracellular calcium increases induced by endothelin-1 (ET-1; ) in A7r5 rat vascular smooth muscle cells (ED50 = 1 nM) and potassium-induced contraction of isolated dog femoral and portal veins (IC50s = 24 and 2.1 nM, respectively). In vivo, it lowers blood pressure in spontaneously hypertensive rats (SHRs) when administered at a dose of 10 mg/kg and inhibits left ventricular hypertrophy in rats induced by isoproterenol when administered at a dose of 3 mg/kg. Formulations containing manidipine have been used in the treatment of hypertension.

Chemische Eigenschaften

Light Yellow Crystalline Solid

Verwenden

Manidipine (Manyper) is a lipophilic, third-generation, highly vasoselective dihydropyridine calcium antagonist with an IC50 of 2.6 nM. It causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. It

Manidipine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Manidipine 4-Methylen-2-oxetanon Methyl-3-aminocrotonat Manidipine hydrochloride 2-Piperazin-1-ylethanol Diisopropylether Magnesiumsulfat 2-(4-Benzhydrylpiperazino)ethyl acetoacetate Methylhydrogen-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridin-3,5-dicarboxylat 2-(4-benzhydrylpiperazin-1-yl)ethanol Methyl 3-nitrobenzylideneacetoacetate 3-Nitrobenzaldehyd 1-Benzhydrylpiperazin

Downstream Produkte

Manidipine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 126)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd. 		18871490254
linda@hubeijusheng.com CHINA 28180 58
Accela ChemBio Inc. 		(+1)-858-699-3322
info@accelachem.com United States 19965 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63711 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
SIMAGCHEM CORP 		+86-13806087780
 sale@simagchem.com China 17367 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167
 1026@dideu.com China 9271 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 29118 58
Baoji Guokang Bio-Technology Co., Ltd. 		0917-3909592 13892490616
 gksales1@gk-bio.com China 9339 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6393 58

89226-50-6()Verwandte Suche:

Dimethylsulfid N,N-Dimethylformamid Manidipine hydrochloride 1,4-Dihydro-2,6-dimethyl-4-(2-ni-trophenyl)-3,5-pyridindicarbon-säure-dimethylester Dichlor(diphenyl)silan Nimodipin 1,5-Diphenylcarbonohydrazid 1,3-Diphenyl-2-thioharnstoff Amlodipine 3,4'-DIAMINODIPHENYLMETHANE Dimethylfumarat Dimethyl ether Chlordiphenylphosphin Dimethylsulfoxid Dimethylphthalat Dimethoxydiphenylsilan Ethan Methyl
  • 2-(4-Diphenylmethyl-1-piperazinyl)ethyl methyl-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(diphenylmethyl)-1-piperazinyl)ethyl methyl ester
  • 89226-75-5 (Di-hydrochloride)
  • 1-diphenylmethyl-4-(2-hydroxyethyl)piperazine
  • 3-{2-[4-(diphenylMethyl)piperazin-1-yl]ethyl} 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Manidipine (Manyper)
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-Methyl 2,6-diMethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
  • MANIDIPINE: MANIDIPINE DIHYDROCHLORIDE
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester (9CI)
  • Franidipine
  • Manidipine 6300
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 5-methyl 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] ester
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)piperazin-1-yl]ethyl]5-methyl ester
  • 3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridi
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl]5-methyl ester
  • Manidipine
  • 2-(4-(Diphenylmethyl)-1-piperazinyl)ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Manidipine(CV-4093)
  • MANIDIPINE;CV-4093;FRANIDIPINE;(±)-MANIDIPINE
  • Manidipine（base）
  • Artedil
  • Iperten
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[4-(diphenylmethyl)-1-piperazinyl]ethyl] 5-methyl ester
  • Manidipine (10mM in DMSO)
  • Manidipine Impurity1254
  • Calcium Channel,Manidipine,Inhibitor,inhibit,Ca channels,Ca2+ channels
  • 89226-50-6
  • 120096-68-4
  • Inhibitors
  • Artedil, Iperten
  • Dihydropyridine
  • Dihydropyridine Class Chemicals
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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