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Alloxan Produkt Beschreibung

CAS-Nr.50-71-5
Bezeichnung:Alloxan
Englisch Name:Alloxan
Synonyma:
ALOXAN;ALLOXAN;Alloxane;ALLOXAN 98%;Mesoxalurea;Alloxan 7169;MESOXALYLUREA;Urea, mesoxalyl-;yrimidinetetrone;Alloxan(Hydrate)
CBNumber:CB4719885
Summenformel:C4H2N2O4
Molgewicht:142.07
MOL-Datei:50-71-5.mol
Alloxan physikalisch-chemischer Eigenschaften
Schmelzpunkt:: ~245 °C (dec.)
Siedepunkt:: 259.59°C (rough estimate)
Dichte: 1.8588 (rough estimate)
Brechungsindex: 1.4610 (estimate)
storage temp. : 2-8°C
pka: pK (25°) 6.63
CAS Datenbank: 50-71-5(CAS DataBase Reference)
NIST chemische Informationen: Alloxan(50-71-5)
EPA chemische Informationen: 2,4,5,6(1H,3H)-Pyrimidinetetrone(50-71-5)
Sicherheit
Kennzeichnung gefährlicher: Xn
R-Sätze:: 20/21/22-36/37/38
S-Sätze:: 26-36
WGK Germany : 3
F : 8-10-23
Giftige Stoffe Daten: 50-71-5(Hazardous Substances Data)

Alloxan Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
White crystals, become pink on exposure to air; colorless aqueous solution which imparts pink color to skin. Soluble in water and alcohol.
Verwenden
Biochemical research, cosmetics, organic synthesis.
Definition
ChEBI: A member of the class of pyrimidones, the structure of which is that of perhydropyrimidine substituted at C-2, -4, -5 and -6 by oxo groups.
Sicherheitsprofil
Poison by intraperitoneal, intravenous, subcutaneous, and rectal routes. Moderately toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Produces dlabetes in experimental animals. Decomposes in storage to release CO2. Do not store in sealed container. Explodes when heated above 170℃. When heated to decomposition it emits toxic fumes of NOx,.
Enzyminhibitor
This sulfhydryl reagent (FW = 142.07 g/mol; CASs = 50-71-5 (free base) and 2244-11-3 (monohydrate)), also named as 2,4,5,6-tetraoxopyrimidine, is an unstable tetraoxopyrimidine that induces diabetes by selectively destroying pancreatic b-cells in laboratory animals upon selective uptake via the GLUT2 transporter. Protocol for Using Alloxan to Induce Diabetes: Step-1: Weigh and measure baseline blood glucose level of mice (Age: 6 weeks or older), adhering to the IACUC Guidelines for Glucose Monitoring of Blood. Step-2: Inject i.v. or i.p. with alloxan (70-90 mg/kg). Step-3: Beginning the day after the alloxan injection, blood glucose levels of each mouse should be checked daily or every other day for 5-7 days. Within 2-3 days after onset of diabetes (as indicated by blood glucose levels), mice should be implanted with an insulin-secreting pellet, when long-term study is necessary. Pellets typically release 0.1 U each 24 hr for >30 days). Mice weighing less than 25 grams require one insulin pellet; larger mice typically receive two insulin pellets to restore normoglycemia. Target(s): hexokinase (1,5,24-28,59); glucokinase (2,60,63,64, 66); succinate dehydrogenase (3,4,41,56); phosphofructokinase (6,9,26); alcohol dehydrogenase, yeast (7); glucose-6 phosphatase (8,23); aconitase (10,57,65); ATPase (11,12); arylamine acetyltransferase (13,14); carbonic anhydrase, weakly inhibited (15); choline acetyltransferase (16); choline dehydrogenase (17); choline oxidase (18); cytochrome oxidase (19,20); fructose-1,6-bisphosphatase (21); galactonolactone dehydrogenase (22); alkaline phosphatase (29,30,50); phosphoglucomutase (23,31); glyceraldehyde-3-phosphate dehydrogenase (32); phosphoprotein phosphatase (33,52); pyrophosphatase (11,12,34,49,51); pyruvate decarboxylase (36-38); rhodanese, or thiosulfate sulfurtransferase (39); sedoheptulokinase (40); succinate oxidase (42,43); urease (44); xanthine oxidase (45,73); adenylate cyclase, Phycomyces blakesleeanus (47); stearate dehydrogenase (48); acid phosphatase (50,72); allantoinase, weakly inhibited (53); oxidative phosphorylation, moderately inhibited (54); protein O-linked N-acetylglucosaminyl-transferase (55); Na+/K+- exchanging ATPase (56); calmodulin-dependent protein kinase (58,67); Ca2+-dependent ATPase (61,62); isocitrate dehydrogenase, NAD (65); glutamate dehydrogenase (65); a-ketoglutarate dehydrogenase (65); succinyl-CoA synthetase (65); fumarase (65); citrate synthase, moderately inhibited (65); isocitrate dehydrogenase, NADP (65); phosphate transport (68); xanthine dehydrogenase (69); papain (70); cathepsin (70); barbiturase (71).
läuterung methode
Crystallisation from water gives the tetrahydrate. Anhydrous crystals are obtained by crystallisation from acetone, glacial acetic acid or by sublimation in vacuo. [See below and Beilstein 24 H 500, 24 I 428, 24 II 301, 24 III/IV 2137.]
Alloxan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Riboflavin
Alloxan Anbieter Lieferant Produzent Hersteller Vertrieb Händler.      Global( 69)Lieferanten     
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733sales@mainchem.com CHINA 32457 55
Hubei Jusheng Technology Co.,Ltd.
86-188-71490254
peter@hubeijusheng.com CHINA 20094 58
Beijing Ouhe Technology Co., Ltd +86-10-4006331231;+86-10-51280831;+86-10-82967028
+86-10-82967029sales@ouhechem.com China 12500 60
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078,021-50426030
86-021-50426522,50426273sales@jingyan-chemical.com China 10012 60
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
86-21-63290778 86-21-63218885sj_scrc@sinopharm.com China 9851 79
Hangzhou Yuhao Chemical Technology Co., Ltd 0571-82693216
+86-571-82880190info@yuhaochemical.com China 9409 52
Jinan Haohua Industry Co., Ltd 0531-58773082 ;58773060
0531-58773099sales@jnhaohua.com China 5587 58
Chengdu Ai Keda Chemical Technology Co., Ltd. 4008-755-333 ; 028-86676798 ; 028-86757656
028-86757656aikeshiji@163.com China 9760 55
Beijing HuaMeiHuLiBiological Chemical 010-56205725;010-86181995
010-65763397waley188@sohu.com China 12343 58
Cheng Du Micxy Chemical Co.,Ltd 028-85632863 028-64559668 18048500443
028-85632863 QQ: 2509670926micxysales@163.com China 13076 58
 
50-71-5(Alloxan)Verwandte Suche:
Pyrimidin Barbitursure 5,5'-Dihydroxy-5,5'-bipyrimidinhexaon 5-Hydroxyiminobarbitursure Alloxan (4-Amino-N-pyrimidin-2-ylbenzolsulfonamidato-NN,O1)silber Flucytosin Trimethoprim Uracil Sulfadiazin Cytosin Pyrimethamin
ALLOXAN 2,4,5,6(1H,3H)-PYRIMIDINETETRONE MESOXALYLUREA MESOXALYLCARBAMIDE ,4,5,6-Pyrimidinetetrone 2,4,5,6-pyrimidintetron 2,4,5,6-Pyrimidintetrone 2,4,5,6-Tetraoxohexahydropyrimidine 5-oxo-barbituricaci Alloxan 7169 Alloxane Barbituric acid, 5-oxo- Pyrimidine-2,4,5,6(1H,3H)-tetraone Urea, mesoxalyl- yrimidinetetrone MESOXALYLCARBAMIDE 98% MESOXALYLUREA 98% ALLOXAN 98% Alloxan(Hydrate) AlloxanTetrahydrate99% ALLOXAN 4-HYDRATE Mesoxalurea 1,3-diazinane-2,4,5,6-tetrone ALOXAN 2,4,5,6(1H,3H)-Pyrimidinetetraone 2 4 5 6(1H 3H)-PYRIMIDINETETRONE 98% 2,4,5,6-Pyrimidinetetrone 5-Oxobarbituric acid alloxan:2,4,5,6(1h,3h)-pyrimidinetetraone Pyrimidine-2,4,5,6(1H,3H)-tetraone monohydrate 50-71-5 C4H2N2O4 C4H2N2O44H20 Analytical Chromatography Product Catalog Analytical Reagents
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