Tacrolimus Monohydrate
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- CAS-Nr.
- 109581-93-3
- Englisch Name:
- Tacrolimus Monohydrate
- Synonyma:
- Tacrolimus monohydrate;FK-506;135175;CS-1308;Tacarolimus;[3R[E(1S,3S,4S);tacrolimushydrate;FK-506 MONOHYDRATE;Tacrolimus (150 mg);FR900506 monohydrate
- CBNumber:
- CB4772400
- Summenformel:
- C44H71NO13
- Molgewicht:
- 822.05
- MOL-Datei:
- 109581-93-3.mol
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Tacrolimus Monohydrate Eigenschaften
- Schmelzpunkt:
- 127-129°
- alpha
- D23 -84.4° (c = 1.02 in chloroform)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble20mg/mL
- Aggregatzustand
- powder
- Farbe
- White to Almost white
- Merck
- 14,9025
- InChIKey
- NWJQLQGQZSIBAF-MLAUYUEBSA-N
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
T |
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| R-Sätze: |
25 |
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| S-Sätze: |
45 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
KD4201200 |
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| HazardClass |
6.1 |
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| PackingGroup |
III |
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| HS Code |
2934990002 |
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| Toxizität |
LD50 i.p. in mice: >200 mg/kg (Kino); LD50 in male, female rats (mg/kg): 57.0, 23.6 i.v.; 134, 194 orally (Ohara) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
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Tacrolimus Monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Verwenden
immune suppressant, antifungal
Definition
ChEBI: A hydrate that is the monohydrate form of tacrolimus.
Biologische Aktivität
Potent calcineurin (protein phosphatase 2B) inhibitor that requires FK 506-binding protein 12 (FKBP12) for activity (IC 50 = 3 nM). Inhibits secretion of IL-1, IL-2 (IC 50 = 1 nM), IL-3, IL-4, IL-6 (IC 50 = 35 nM), GM-CSF, TNF α (IC 50 = 10 nM), IFN γ and Myc from activated T-cells in vitro . Exhibits potent immunosuppressive, neuroprotective and anticonvulsant activity in vivo .
Sicherheitsprofil
A poison by ingestion and intravenous routes. When heated to decomposition it emits toxic vapors of NOx.
Tacrolimus Monohydrate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tacrolimus Monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 246)Lieferanten
109581-93-3()Verwandte Suche:
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-, monohydrate, [3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-
- TACROLIMUS HYDRATE/TSUKUBAENOLIDE HYDRATE
- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
- Tacrolimus (150 mg)
- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-Methoxycyclohexyl]-1-Methylethenyl]-14,16-diMethoxy-4,10,12,18-tetraMethyl-8-(2-propen-1-yl)-
- FK-506 monohydrate, >=98%
- Tacrolimus /FK506 monohydrate
- ,8s*,9e,12r*,14r*,15s*,16r*,18s*,19s*,26ar*))-
- 18-tetramethyl-8-(2-propenyl)-,monohydrate,(3s-(3r*(e(1s*,3s*,4s*)),4s*,5r*
- 3-(2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl)-14,16-dimethoxy-9,10,12,
- tacrolimushydrate
- tsukubaenolidehydrate
- FK-506 MONOHYDRATE
- Tacarolimus
- 15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-te
- Tacrolimus Monohydrate CAS 109581-93-3
- FK506 Monohydrate[Tacrolimus Hydrate]
- 135175
- CS-1308
- FK 506 monohydrate, Tacrolimus
- Tacrolimus monohydroate
- TacrolimusMonohydrate>
- Tacrolimus monohydrate CRS
- FR900506 monohydrate
- Tacrolimus monohydrate (Fujimycin monohydrate
- [3R[E(1S,3S,4S)
- (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone monohydrate
- Tacrolimus monohydrate (Y0001926)
- Tacrolimus (1642802)
- FK-506
- Tacrolimus monohydrate
- Lecithin Impurity 9 (L-α-Phosphatidylinositol)
- Tacrolimus USP/IP/PH.Eur
- Tacrolimus Reference Standard
- 109581-93-3
- C44H69NO12H2O
- Cell Signaling and Neuroscience
- Kinase/Phosphatase Biology
- Protein Phosphatase 2B (Calcineurin/PP2B)
- Serine/Threonine Phosphatase Inhibitors
- BioChemical
- Cell Biology
- Signalling
