Amicarbalidisetionat

amicarbalide isetionate  Struktur
3671-72-5
CAS-Nr.
3671-72-5
Bezeichnung:
Amicarbalidisetionat
Englisch Name:
amicarbalide isetionate
Synonyma:
Diisethionate;amicarbalide isetionate;Amicarbalide isethionate;amicarbalide diisethionate
CBNumber:
CB4910325
Summenformel:
C15H16N6O.2C2H6O4S
Molgewicht:
548.595
MOL-Datei:
3671-72-5.mol

Amicarbalidisetionat Eigenschaften

Schmelzpunkt:
209° (decomp 256°)

Sicherheit

Toxizität LD50 in mice, rats (mg/kg): 168, 186 s.c. (Beveridge)

Amicarbalidisetionat Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Diampron,May and Baker

Manufacturing Process

m-Aminobenzonitrile (50 g) in anhydrous pyridine (200 ml) was treated with a solution of phosgene (15 ml) in anhydrous toluene (100 ml) over 10 min with mechanical stirring. The red solution was heated for 0.5 hour on the steam bath, cooled, and added to water (2 litres). The pale grey precipitate was filtered off, washed with ether, and crystallised from methanol (250 ml). N,N1- Di(m-cyanophenyl)urea separated as grey prisms, melting point 205-206°C.
A suspension of N,N1-di(m-cyanophenyl)urea (42 g) in anhydrous chloroform (420 ml), containing anhydrous ethanol (70 ml), was saturated with anhydrous hydrogen chloride at 0-5°C. After setting aside for 2 hours, a clear solution was obtained, which began to crystallise. After a week, the crystals were filtered off, washed well with anhydrous ether, and dried over calcium chloride. The iminoether hydrochloride so obtained (72 g) was added to saturated anhydrous ethanolic ammonia (720 ml), and the suspension heated at 55-60°C for 6 hours. After cooling to 20°C the crystals were filtered off, and recrystallized from 2 N hydrochloric add (300 ml). 3,31- Diamidinodiphenylurea dihydrochloride monohydrate separated as white prisms, melting point 286°C (decomp.).
In practice it is usually used as isethonate salt.

Therapeutic Function

Antiprotozoal

Amicarbalidisetionat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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  • Diisethionate
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