4-Fluorbenzonitril
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- CAS-Nr.
- 1194-02-1
- Bezeichnung:
- 4-Fluorbenzonitril
- Englisch Name:
- 4-Fluorobenzonitrile
- Synonyma:
- PFBN;P-FLUOROBENZONITRILE;For fluorobenzonitrile;4-fluoronitrile;4-florobenzonitrile;P-Fluorobenzonitile;4-fluoro-benzonitril;p-Cyanofluorobenzene;p-fluoro-benzonitril;4-CYANOFLUOROBENZENE
- CBNumber:
- CB5200760
- Summenformel:
- C7H4FN
- Molgewicht:
- 121.11
- MOL-Datei:
- 1194-02-1.mol
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4-Fluorbenzonitril Eigenschaften
- Schmelzpunkt:
- 32-34 °C (lit.)
- Siedepunkt:
- 188 °C/750 mmHg (lit.)
- Dichte
- 1.1070
- Brechungsindex
- 1.4925
- Flammpunkt:
- 150 °F
- storage temp.
- Sealed in dry,Room Temperature
- Löslichkeit
- soluble in Chloroform, Ethyl Acetate
- Aggregatzustand
- Crystalline Low Melting Solid
- Farbe
- White
- Wasserlöslichkeit
- Insoluble in water.
- BRN
- 2041517
- Expositionsgrenzwerte
- NIOSH: IDLH 25 mg/m3
- InChI
- 1S/C7H4FN/c8-7-3-1-6(5-9)2-4-7/h1-4H
- InChIKey
- AEKVBBNGWBBYLL-UHFFFAOYSA-N
- SMILES
- Fc1ccc(cc1)C#N
- CAS Datenbank
- 1194-02-1(CAS DataBase Reference)
- NIST chemische Informationen
- Benzonitrile, 4-fluoro-(1194-02-1)
- EPA chemische Informationen
- 4-Fluorobenzonitrile (1194-02-1)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn,T,Xi |
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| R-Sätze: |
20/21/22-36/37/38 |
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| S-Sätze: |
36/37-36/37/39-26-36 |
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| RIDADR |
UN 1325 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DI4368500 |
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| Hazard Note |
Toxic |
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| TSCA |
TSCA listed |
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| HazardClass |
4.1 |
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| PackingGroup |
Ⅱ |
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| HS Code |
29269095 |
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| Speicherklasse |
4.1B - Flammable solid hazardous materials |
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| Hazard Classifications |
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Flam. Sol. 1 |
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| Toxizität |
mouse,LD50,intraperitoneal,1gm/kg (1000mg/kg),Farmaco, Edizione Scientifica. Vol. 41, Pg. 41, 1986. |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung
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| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H228 |
Entzündbarer Feststoff. |
Entzündbare Feststoffe |
Kategorie 1 |
Achtung
Warnung |
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P210, P240,P241, P280, P370+P378 |
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| Sicherheit |
| P210 |
Von Hitze, heißen Oberflächen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P240 |
Behälter und zu befüllende Anlage erden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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4-Fluorbenzonitril Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
white crystalline low melting solid
Verwenden
4-Fluorobenzonitrile is used in the synthesis of flurenones, pharmaceutical prerequisites, as well as opiod receptor antagonists.
Application
The application of 4-Fluorobenzonitrile in medicinal chemistry has proven valuable, particularly in the design of novel drug candidates that target specific biological pathways. Additionally, 4-Fluorobenzonitrile is employed in the production of dyes and pigments, offering vibrant colors and improved performance in various formulations.
Allgemeine Beschreibung
4-Fluorobenzonitrile undergoes metal-mediated coupling to yield eight-membered thorium(IV) tetraazamacrocycle. It undergoes condensation with diphenylamine to yield monomer 4-cyanotriphenylamine.
Synthese
4-Fluorobenzonitrile is synthesised using 4-Fluorobenzyl alcohol as raw material by chemical reaction. The specific synthesis steps are as follows:
With respect to 2 mmol of each alcohol represented by the general formula (1), 4 ml of CH2Cl2 as a solvent, 0.05 equivalent of TEMPO as an N-nitrosyl compound, (A) t-BuOCl, (B) I 2 or (C ) N, N'-diiodo-5,5-dimethylhydantoin (DIH) were mixed in a predetermined amount and stirred for a predetermined time at room temperature.Next, 1.5 equivalents of I 2 and 4 ml of aqueous ammonia were added, and the mixture was stirred at room temperature for 2 hours.
4-Fluorbenzonitril Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-MORPHOLINOBENZYLAMINE
4-Fluorobenzamidine hydrochloride
4-PIPERAZIN-1-YL-BENZOIC ACID
4-FLUORO-BENZAMIDINE
3-FLUORO-2-(5,5-DIMETHYL-1,3,2-DIOXABORINAN-2-YL)BENZONITRILE
4,4'-(piperazine-1,4-diyl)dibenzonitrile
2-Brom-4-fluorbenzonitril
4-N-BUTOXYBENZONITRILE
3,5-DiMethylMorpholine
Methyl 4-Mercaptobenzoate
4,4',4''-(benzene-1,3,5-triyltris(oxy))tribenzoic acid
1-Fluor-4-(isopropenyl)benzol
4-CYANOTHIOPHENOL
1,4-Bis(1-methylvinyl)benzol
4-CYANOPHENYLACETONITRILE 97
4-(2-METHYLPROPOXY)-BENZENEMETHANAMINE
1-(2-CYANOPHENYL)PIPERAZINE
4-Fluorbenzonitril Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 623)Lieferanten
1194-02-1(4-Fluorbenzonitril)Verwandte Suche:
- Benzonitrile, p-fluoro- (6CI,7CI,8CI)
- The fluorine benzene nitriles
- 4-Fluorobenzonitrile, 97+%
- p-Fluorophenyl cyanide
- P-Fluorobenzonitile
- p-Fluorobenzonitrile 4-Fluorobenzonitrile
- 4-florobenzonitrile
- 3-chloro-4-fluorobenzontrile
- 4-Fluorobenzonitrile98%
- 1-Cyano-4-fluorobenzene
- 1-Fluoro-4-cyanobenzene
- 4-fluoro-benzonitril
- Benzonitrile, p-fluoro-
- p-Cyanofluorobenzene
- p-fluoro-benzonitril
- 4-CYANOFLUOROBENZENE
- 4-FLUOROBENZONITRILE
- 4-Fluorobenzonitrile>
- Crisaborole Related Compound 1
- Benzonitrile, 4-fluoro-
- 4-Fluorobenzonitrile pure, 98%
- PFBN
- P-FLUOROBENZONITRILE
- For fluorobenzonitrile
- Para Fluoro Benzonitrile
- 4-fluoronitrile
- Olaquindox Impurity 13
- 4-Fluorobenzonitrile 99% GC
- 1194-02-1
- Organic Building Blocks
- Nitrogen Compounds
- Cyanides/Nitriles
- Building Blocks for Liquid Crystals
- Benzonitriles (Building Blocks for Liquid Crystals)
- Building Blocks
- C6 to C7
- Pesticide intermediates
- Pyridines
- Fluorobenzene Series
- Aromatic Nitriles
- Fluorobenzene
- Nitrile
- Nitriles
- Fluorine Compounds
- Benzonitriles (Building Blocks for Liquid Crystals)
- Building Blocks for Liquid Crystals
- Functional Materials
- C6 to C7
- Cyanides/Nitriles
- Nitrogen Compounds
- bc0001
- 1194-02-1
