2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
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- CAS-Nr.
- 56741-95-8
- Englisch Name:
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
- Synonyma:
- U-54461;U 54461S;PNU-54461;NSC 149027;bropirimine;Bromopilimine;5-BroMo-6-phenylisocytosine;2-Amino-5-bromo-6-phenylpyrimidin-4-ol;2-AMino-5-broMo-6-phenyl-4-pyriMidinol;2-AMino-5-broMo-6-phenyl-4-pyriMidinone
- CBNumber:
- CB5225165
- Summenformel:
- C10H8BrN3O
- Molgewicht:
- 266.09
- MOL-Datei:
- 56741-95-8.mol
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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Eigenschaften
- Schmelzpunkt:
- 285-287° (Stevens); mp 246-248° (Brown, Stevens)
- Siedepunkt:
- 389.7±52.0 °C(Predicted)
- Dichte
- 1.6292 (rough estimate)
- Brechungsindex
- 1.6520 (estimate)
- storage temp.
- room temp
- Löslichkeit
- DMSO: ≥5mg/mL (warm DMSO)
- Aggregatzustand
- powder
- pka
- 3.18; 8.53(at 25℃)
- Farbe
- white to beige
- Wasserlöslichkeit
- 7.8mg/L(37 ºC)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
63-62 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
UW7351300 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H361 |
Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen. |
Reproduktionstoxizität |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P281 |
Vorgeschriebene persönliche Schutzausrüstung verwenden. |
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2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Bropirimine is an immunomodulator with diverse biological activities. It is a toll-like receptor 7 (TLR7) agonist that inhibits RANKL-induced osteoclast differentiation of murine bone marrow-derived macrophages (BMDMs) in a concentration-dependent manner, an effect that is reversed by an anti-IFN-β antibody. Dietary administration of bropirimine (200 mg/kg twice per week) prevents development of transitional cell carcinomas (TCCs) in a mouse model of carcinogen-induced bladder carcinoma. Bropirimine (100 mg/kg) reduces pulmonary collagen accumulation and bronchoalveolar lavage fluid (BALF) monocyte and eosinophil infiltration in a hamster model of bleomycin-induced lung fibrosis. It also delays disease onset and progression and increases plasma IFN levels in a mouse model of experimental autoimmune encephalomyelitis (EAE).
Verwenden
Bropirimine is an orally active immunostimulant; anticancer agent. Bropirimine is an interferon inducer that is a potentially useful in the the treatment of superficial bladder cancer (transitional cell carcinoma). Studies suggest that Bropirimine has direct antitumor activity rather than a cytokine-mediated antitumor effect.
Biochem/physiol Actions
Bropirimine is an immunostimulating agent. The compound induces production of α and β interferons and enhances NK cell function. Bropirimine has antiproliferative effects in cancer cell lines and tumor growth in in vivo models.
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 86)Lieferanten
56741-95-8()Verwandte Suche:
- 2-Amino-5-bromo-6-phenylpyrimidin-4(3H)-one
- 2-AMINO-4-HYDROXY-5-BROMO-6-PHENYLPYRIMIDINE
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE
- 2-Amino-5-bromo-6-phenylpyrimidin-4-ol
- 2-Amino-5-bromo-6-phenylpyrimidin-4(1H)-one
- 5-Bromo-6-phenyl-2,3-dihydro-2-iminopyrimidin-4(1H)-one
- PNU-54461
- U-54461
- 2-AMino-5-broMo-6-phenyl-4(3H)-pyriMidinone
- 2-AMino-5-broMo-6-phenyl-4-pyriMidinol
- 2-AMino-5-broMo-6-phenyl-4-pyriMidinone
- 5-BroMo-2,3-dihydro-2-iMino-6-phenyl-4(1H)-pyriMidinone
- 5-BroMo-6-phenylisocytosine
- NSC 149027
- 4(3H)-PyriMidinone, 2-aMino-5-broMo-6-phenyl-
- 2-Amino-5-bromo-4-phenyl-6-hydroxypyrimidine
- U 54461S
- 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinon
- 2-amino-5-bromo-6-phenyl-4(1h)-pyrimidinone
- bropirimine
- 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
- 2-amino-5-bromo-6-phenyl-1H-pyrimidin-4-one
- 2-AMINO-5-BROMO-4-HYDROXY-6-PHENYLPYRIMIDINE USP/EP/BP
- carcinoma,antitumour,Bropirimine,tract,immunostimulant,Inhibitor,differentiation,Toll-like Receptor (TLR),urinary,inhibit
- Bromopilimine
- 56741-95-8
- C10H8BrN3O
- Heterocycle-Pyrimidine series
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
