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Ponatinib Hydrochloride Produkt Beschreibung

Ponatinib Hydrochloride Struktur
1114544-31-8
CAS-Nr.
1114544-31-8
Englisch Name:
Ponatinib Hydrochloride
Synonyma:
AP24534-HCl;Ponatinib-HCl;Ponatinib hydrochloride;AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
CBNumber:
CB52657391
Summenformel:
C29H28ClF3N6O
Molgewicht:
569.02
MOL-Datei:
1114544-31-8.mol

Ponatinib Hydrochloride Eigenschaften

Sicherheit

Ponatinib Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.

Originator

Ariad (United States)

Trademarks

Iclusig

Ponatinib Hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Ponatinib Hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 41)Lieferanten
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ATK CHEMICAL COMPANY LIMITED
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career henan chemical co
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Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
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HENAN BON INDUSTRIAL CO.,LTD
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info@hnbon.com CHINA 20535 58
Amadis Chemical Company Limited
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0086-571-89925065 sales@amadischem.com China 132149 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308,QQ:2879822141
028-89481236 service@2hpharm.com CHINA 121 55
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783
+86 (531) 55696010 QQ 1762738062 sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market) China 1856 62

  • AP24534 Mono-hydrochloride
  • Ponatinib Mono-hydrochloride
  • 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
  • Ponatinib hydrochloride
  • Ponatinib-HCl
  • AP24534-HCl
  • 1114544-31-8
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