Ponatinib Hydrochloride
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Ponatinib Hydrochloride Chemical Properties,Uses,Production
Description
In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.Originator
Ariad (United States)brand name
IclusigPonatinib Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Ponatinib Hydrochloride Suppliers
Global( 41)Suppliers
| Supplier | Tel | Fax | Country | ProdList | Advantage | |
|---|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +86 21 5161 9050/ 5187 7795 |
+86 21 5161 9052/ 5187 7796 | ivan@atkchemical.com | CHINA | 24698 | 60 |
| career henan chemical co | +86-371-86658258 |
sales@coreychem.com | CHINA | 30050 | 58 | |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 |
+86-755-23284190 | sales@tianpharm.com | CHINA | 305 | 58 |
| Biochempartner | 0086-13720134139 |
candy@biochempartner.com | CHINA | 969 | 58 | |
| Shochem(Shanghai) Co.,Ltd | 86-21-50800795 |
info@shochem.com | CHINA | 283 | 58 | |
| Beijing Yibai Biotechnology Co., Ltd | 0086-182-6772-3597 |
sales03@yibaibiotech.com | CHINA | 420 | 58 | |
| HENAN BON INDUSTRIAL CO.,LTD | 0371-55170695 |
info@hnbon.com | CHINA | 20536 | 58 | |
| Amadis Chemical Company Limited | 0086-571-89925085 |
0086-571-89925065 | sales@amadischem.com | China | 132151 | 58 |
| Chengdu Henghui Pharm Tec Co. Ltd. | 13540674322 15828370308，QQ：2879822141 |
028-89481236 | service@2hpharm.com | CHINA | 121 | 55 |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 |
+86 (531) 55696010 QQ 1762738062 | sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market) | China | 1857 | 62 |
View Lastest Price from Ponatinib Hydrochloride manufacturers
| Image | Release date | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2019-09-02 |
Ponatinib Hydrochloride 1114544-31-8 |
US $1.00-2.00 / KG | 1KG | 95.0-99.8% | 1KG;5KG 10KG; 100KG | career henan chemical co | |
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2019-08-16 |
Ponatinib Hydrochloride 1114544-31-8 |
US $0.00-0.00 / KG | 1g | 99% | 50kg/month | Beijing Yibai Biotechnology Co., Ltd |
1114544-31-8(Ponatinib Hydrochloride)Related Search:
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- 1114544-31-8
