ChemicalBook
Chinese Japanese Germany Korea

Ponatinib Hydrochloride

Ponatinib Hydrochloride
Ponatinib Hydrochloride structure
CAS No.
1114544-31-8
Chemical Name:
Ponatinib Hydrochloride
Synonyms
AP24534-HCl;Ponatinib-HCl;Ponatinib hydrochloride;AP24534 Mono-hydrochloride;Ponatinib Mono-hydrochloride;3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
CBNumber:
CB52657391
Molecular Formula:
C29H28ClF3N6O
Formula Weight:
569.02
MOL File:
1114544-31-8.mol

Ponatinib Hydrochloride Properties

FDA UNII
96R6PU3D8J

Ponatinib Hydrochloride Chemical Properties,Uses,Production

Description

In December 2012, the US FDA approved ponatinib (also referred to as AP 24534) for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronicmyeloid leukemia (CML). Ponatinib is a pan-Bcr–Abl TKI that blocks both the native (IC50=0.4 nM) and Bcr– AblT315I mutated kinases (IC50=2.0 nM) in addition to othermutated kinases in CML patients. In the Ba/F3 cell proliferation assay, ponatinib inhibits ABL and the T315I Abl mutant with IC50s of 1.2 and 8.8 nM, respectively. Ponatinib was identified by a structure-based drug design approach. Ponatinib binds to the kinase domain in a DFG-out conformation; the ethynyl moiety helps the inhibitor evade the mutant gatekeeper isoleucine residue at position 315. In addition to Abl and the T315I mutant of Abl, ponatinib inhibits VEGFR, PDGFR, FGFR, SRC, KIT, RET, TIE2, FLT3, and EPH receptors at concentrations ranging from0.1 to 20 nM.

Originator

Ariad (United States)

brand name

Iclusig

Ponatinib Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products


Ponatinib Hydrochloride Suppliers

Global( 41)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 24698 60
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30050 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Biochempartner
0086-13720134139
candy@biochempartner.com CHINA 969 58
Shochem(Shanghai) Co.,Ltd
86-21-50800795
info@shochem.com CHINA 283 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales03@yibaibiotech.com CHINA 420 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 20536 58
Amadis Chemical Company Limited
0086-571-89925085
0086-571-89925065 sales@amadischem.com China 132151 58
Chengdu Henghui Pharm Tec Co. Ltd. 13540674322 15828370308,QQ:2879822141
028-89481236 service@2hpharm.com CHINA 121 55
Jinan Trio PharmaTech Co., Ltd. +86 (531) 88811783
+86 (531) 55696010 QQ 1762738062 sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market) China 1857 62

View Lastest Price from Ponatinib Hydrochloride manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-09-02 Ponatinib Hydrochloride
1114544-31-8
US $1.00-2.00 / KG 1KG 95.0-99.8% 1KG;5KG 10KG; 100KG career henan chemical co
2019-08-16 Ponatinib Hydrochloride
1114544-31-8
US $0.00-0.00 / KG 1g 99% 50kg/month Beijing Yibai Biotechnology Co., Ltd

1114544-31-8(Ponatinib Hydrochloride)Related Search:


  • AP24534 Mono-hydrochloride
  • Ponatinib Mono-hydrochloride
  • 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide hydrochloride
  • Ponatinib hydrochloride
  • Ponatinib-HCl
  • AP24534-HCl
  • 1114544-31-8
Copyright 2017 © ChemicalBook. All rights reserved