EGFR Inhibitor III

733009-42-2

CAS-Nr.: 733009-42-2

Englisch Name:: EGFR Inhibitor III

Synonyma:: EGFR Inhibitor III;EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem;Acetamide, 2-chloro-N-[4-[(4,5-dichloro-2-fluorophenyl)amino]-6-quinazolinyl]-

CBNumber:: CB53136747

Summenformel:: C16H10Cl3FN4O

Molgewicht:: 399.63

MOL-Datei:: 733009-42-2.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 3

EGFR Inhibitor III Eigenschaften

Schmelzpunkt:: >300 °C

Siedepunkt:: 566.7±50.0 °C(Predicted)

Dichte: 1.607±0.06 g/cm3(Predicted)

storage temp.: -20C

Aggregatzustand: Yellow solid

pka: 11.18±0.43(Predicted)

Sicherheit

EGFR Inhibitor III Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

EGFR Inhibitor III is which inhibits EGFR- kinase activity, blocking phosphorylation.

Allgemeine Beschreibung

A cell-permeable quinazolinyl-chloroacetamide compound that selectively and irreversibly blocks EGFR autophosphorylation with no effect on the expression levels of EGFR, and suppresses leiomyoma and myometrical cell proliferation (IC₅₀ = 0.7 μM and 1.1 μM, respectively). Shown to induce apoptosis and cell cycle arrest, and in combination with Genistein (Cat. No. 345834) completely suppress leiomyoma cell proliferation.

Biochem/physiol Actions

Target IC50: 0.7 μM and 1.1 μM suppressesing leiomyoma and myometrical cell proliferation, respectively

EGFR Inhibitor III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

EGFR Inhibitor III Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 3)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

EGFR Inhibitor III
EGFR Inhibitor III - CAS 733009-42-2 - Calbiochem
Acetamide, 2-chloro-N-[4-[(4,5-dichloro-2-fluorophenyl)amino]-6-quinazolinyl]-
733009-42-2
C16H10Cl3FN4O