S-4-bromobenzylglutathione cyclopentyl diester

S-4-bromobenzylglutathione cyclopentyl diester Struktur
166038-00-2
CAS-Nr.
166038-00-2
Englisch Name:
S-4-bromobenzylglutathione cyclopentyl diester
Synonyma:
BBGC;BBGD;BrBzGCp2;BrBzGCp2,BrBzGCp-2;S-p-Bromobenzylglutathione cyclopentyl diester;S-4-bromobenzylglutathione cyclopentyl diester;S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC);Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
CBNumber:
CB61384475
Summenformel:
C27H38BrN3O6S
Molgewicht:
612.58
MOL-Datei:
166038-00-2.mol

S-4-bromobenzylglutathione cyclopentyl diester Eigenschaften

Siedepunkt:
790.6±60.0 °C(Predicted)
Dichte
1.38±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
Löslichkeit
DMSO: 250 mg/mL (408.11 mM)
Aggregatzustand
powder
pka
12.84±0.46(Predicted)
Farbe
white to beige

Sicherheit

S-4-bromobenzylglutathione cyclopentyl diester Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

S-p-Bromobenzylglutathione cyclopentyl diester has been used as an inhibitor of glyoxalase 1?(GLO-1) enzyme to treat HL-1 cardiomyocytes for stimulating aging-based glycative stress. It has also been used as an inhibitor of GLO-1 in hepatic stellate cells.

Biochem/physiol Actions

S-p-Bromobenzylglutathione cyclopentyl diester (BBGC) is a cell-permeable inhibitor of Glyoxalase 1 (GLO1), an enzyme that detoxifies methylglyoxal, a toxic side-product of glycolysis that induces apoptosis at high levels and has been linked to arterial atherogenesis in diabetics. However, tumors use GLO as well and overexpression of GLO1 has been reported in a number of cancers, so GLO1 inhibitors including BBCG have been investigated as possible anticancer agents. Recent studies have indicated that methylglyoxal has some beneficial effects at low levels with GABAA receptor agonist activity, and that GLO1 inhibition with BBGC can reduce anxiety-like behavior and decrease antiseizure activity. S-p-bromobenzylglutathione cyclopentyl diester should be an inportant tool to study the glyoxalase system.

S-4-bromobenzylglutathione cyclopentyl diester Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


S-4-bromobenzylglutathione cyclopentyl diester Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 9)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Energy Chemical 021-58432009 400-005-6266
marketing1@energy-chemical.com China 44843 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 15801484223;
psaitong@jm-bio.com China 29778 58
TargetMol Chemicals Inc. 4008200310
marketing@tsbiochem.com China 23980 58
Shanghai Maclean Biochemical Technology Co., LTD 021-50706066 15221275939
shenlinxing@macklin.cn China 29802 58

  • S-4-bromobenzylglutathione cyclopentyl diester
  • BBGD
  • BBGC
  • BrBzGCp2
  • S-p-Bromobenzylglutathione cyclopentyl diester >=98% (HPLC)
  • Glycine, N-[S-[(4-bromophenyl)methyl]-N-L-γ-glutamyl-L-cysteinyl]-, dicyclopentyl ester (9CI)
  • S-p-Bromobenzylglutathione cyclopentyl diester
  • BrBzGCp2,BrBzGCp-2
  • 166038-00-2
  • C27H38BrN3O6S
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