Benzimidazol-2-ylamin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R43:Sensibilisierung durch Hautkontakt möglich.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
Light yellow to cream or beige powder or flakes. N,N'-o-Phenyleneguanidine [934-32-7], 2-aminobenzimidazole, C7H7N3, Mr 133.15, mp 231 – 232 ℃(decomp.), obtained by cyclization of o-phenylenediamine with cyanogen chloride or cyanamide, is the nucleus for a number of compounds of economic interest.
Definition
ChEBI: 2-aminobenzimidazole is a member of the class of benzimidazoles that is benzimidazole in which the hydrogen at position 2 is replaced by an amino group. It has a role as a marine xenobiotic metabolite.
synthetische
Synthesis of 2-aminobenzimidazole: Cyanogen bromide (3.5 g., 0.034 mole) was added in small portions, with shaking, to a suspension of o-phenylenediamine (4.2 g. , 0.34 mole) in water (40 ml), the exothermic reaction mixture was cooled to room temperature and it was stirred for 36hrs. The solution was filtered after standing overnight. Sodium hydroxide (1.4 g., 0.034 mole) in 30 ml of water was then added and the solution was evaporated. The solid thus obtained was filtered and recrystalized from water. Yield 85%, m.p. 228 - 230°C
Allgemeine Beschreibung
Plates (in water); white powder.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
2-Aminobenzimidazole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition 2-Aminobenzimidazole emits toxic fumes of nitrogen oxides.
Brandgefahr
Flash point data for 2-Aminobenzimidazole are not available; however, 2-Aminobenzimidazole is probably combustible.
Sicherheitsprofil
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic NO,. See also AROUTIC AMINES.
Benzimidazol-2-ylamin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Oxibendazol
2-AMINO-1-METHYLBENZIMIDAZOLE
2-BROMO-1H-BENZIMIDAZOLE
1H-Benzimidazol-2-amine, 1-(2-methoxyphenyl)-
Pyrimido[1,2-a]benzimidazole, 2,4-dimethyl- (6CI,7CI,8CI,9CI)
1H-Benzimidazole,2,2'-azobis- (9CI)
1H-Benzimidazol-2-amine,1-butyl-(9CI)
1H-Benzimidazol-2-amine, 1-[(4-methylphenyl)methyl]-
1H-Benzimidazol-2-amine,1-(1-methylethyl)-(9CI)
1H-Benzimidazol-2-amine, 1-(4-methoxyphenyl)-
