7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
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- CAS-Nr.
- 52029-86-4
- Englisch Name:
- 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- Synonyma:
- STO-609 ACETATE;STO-609;STO-609, >98%;STO609;STO 609;STO-609 free base;STO-609 ACETIC ACID;STO-609, 10 mM in DMSO;STO-609 - CAS 52029-86-4 - Calbiochem;7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid;7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-
- CBNumber:
- CB6245603
- Summenformel:
- C19H10N2O3
- Molgewicht:
- 314.29
- MOL-Datei:
- 52029-86-4.mol
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7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE Eigenschaften
- Schmelzpunkt:
- >300 °C
- Siedepunkt:
- 716.9±62.0 °C(Predicted)
- Dichte
- 1.54±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- Löslichkeit
- DMSO: 15 mg/mL at ≥60 °C
- Aggregatzustand
- solid
- pka
- 2.65±0.20(Predicted)
- Farbe
- Light yellow to yellow
- InChI
- 1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24)
- InChIKey
- MYKOWOGZBMOVBJ-UHFFFAOYSA-N
Sicherheit
| S-Sätze: |
22-24/25 |
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| WGK Germany |
3 |
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| Speicherklasse |
11 - Combustible Solids |
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7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid is a calcium/calmodulin-dependent protein kinase inhibitor and was found to upregulate various AhR target genes in human macrophages.
Biologische Aktivität
Selective, cell-permeable inhibitor of Ca 2+ -calmodulin-dependent protein kinase kinase (K i values are 80 and 15 ng/ml for inhibition of CaM-KK α and CaM-KK β respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 112)Lieferanten
52029-86-4()Verwandte Suche:
- STO-609
- STO-609 ACETIC ACID
- 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid - acetic acid
- 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic Acid
- 7H-BENZ[DE]BENZIMIDAZO[2,1-A]ISOQUINOLINE-7-ONE-3-CARBOXYLIC ACID, ACETATE
- 7-OXO-7H-BENZIMIDAZO[2,1-A]BENZ[DE]ISOQUINOLINE-3-CARBOXYLIC ACID ACETATE
- STO-609, >98%
- STO609;STO 609
- STO-609 - CAS 52029-86-4 - Calbiochem
- STO-609 free base
- 7H-Benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid, 7-oxo-
- STO-609 ACETATE
- STO-609,Autophagy,AMP-activated protein kinase,AMPK,STO609,Calmodulin-dependent protein kinases,Inhibitor,Calmodulin-dependent kinases,CaMK,inhibit
- STO-609, 10 mM in DMSO
- 52029-86-4
- C19H10N2O3C2H4O2
- Kinase/Phosphatase Biology
- Serine/Threonine Kinase Inhibitors
- Calcium/Calmodulin Protein Kinase Kinase (CaMKK)
- Cell Biology
- Cell Signaling and Neuroscience
- BioChemical
- Protein Kinase
