(±)-JQ1

1268524-69-1

CAS-Nr.: 1268524-69-1

Englisch Name:: (±)-JQ1

Synonyma:: rac JQ-1;(+/-)-JQ1;(+/-)-SGCBD01;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate

CBNumber:: CB62589817

Summenformel:: C23H25ClN4O2S

Molgewicht:: 456.99

MOL-Datei:: 1268524-69-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 25

(±)-JQ1 Eigenschaften

Siedepunkt:: 610.4±65.0 °C(Predicted)

Dichte: 1.33±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: soluble2mg/mL, clear (warmed)

pka: 2.05±0.60(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Stabilität:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Sicherheit

WGK Germany	3

(±)-JQ1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(±)-JQ1 has been used to study its effect on adipogenesis, by analysing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN′s substrate recruiting function in mouse and human.

Biochem/physiol Actions

(±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.

(±)-JQ1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

(±)-JQ1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 25)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Henan Alfa Chemical Co., Ltd	+8618339805032	alfa4@alfachem.cn	China	12755	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131981	58
Taizhou Tongxin Bio-Tech Co., Ltd	0523-18601685-898 18652728585	sales@allyrise.com	China	2743	60
Shanghai YuanQi Biotechnology Co., Ltd.	+86-2332782371 +86-18120098618	sales@adobechem.com	China	1250	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Taizhou Ruixin Chemical Co., Ltd.	0576-89085261 15867635987	jasonhu09@163.com	China	442	50
Chengdu Saint - Kay Biotechnology Co., Ltd.	028-85157043 15882256948	676046971@qq.com	China	4391	58

[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester
tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
(+/-)-SGCBD01
rac JQ-1
6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester
(+/-)-JQ1
tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
1268524-69-1