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Diphenoxylathydrochlorid Produkt Beschreibung

DIPHENOXYLATE HYDROCHLORIDE Struktur
3810-80-8
CAS-Nr.
3810-80-8
Bezeichnung:
Diphenoxylathydrochlorid
Englisch Name:
DIPHENOXYLATE HYDROCHLORIDE
Synonyma:
r1132;DIPHENOXYLATE HCL;DIPHENOXYLATE HYDROCHLORIDE;Diphenoxylate hydrochloride solution;Diphenoxylate for system suitability;Diphenoxylate Hydrochloride CII (200 mg);Diphenoxylate HCL (Subj To Narcotic Permit);DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION;DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI;Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
CBNumber:
CB6305387
Summenformel:
C30H33ClN2O2
Molgewicht:
489.05
MOL-Datei:
3810-80-8.mol

Diphenoxylathydrochlorid Eigenschaften

Schmelzpunkt:
220.5-222°
storage temp. 
-20°C
Löslichkeit
Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
RIDADR  1544
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933330000
Bildanzeige (GHS)
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizität oral Kategorie 3 Achtung P264, P270, P301+P310, P321, P330,P405, P501
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung P261, P285, P304+P341, P342+P311,P501
Sicherheit
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.

Diphenoxylathydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

White or almost white, crystalline powder.

Originator

Lomotil,Searle,US,1960

Verwenden

Antiperistaltic; antidiarrheal. Controlled substance (opiate).

Definition

ChEBI: The hydrochloride salt of diphenoxylate.

Manufacturing Process

A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15 parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for 24 hours at 100-120°C and then cooled and filtered to remove the precipitate of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The filtrate is then extracted with dilute hydrochloric acid and the extract is rendered alkaline by addition of concentrated aqueous potassium hydroxide and extracted with ether. This ether extract is treated with gaseous hydrogen chloride. The resulting precipitate is collected on a filter. The hydrochloride of the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'- piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl ester.

Therapeutic Function

Antidiarrheal

Veterinary Drugs and Treatments

Diphenoxylate is an opiate in combination with atropine in antidiarrheal products used primarily in dogs; it also has antitussive properties. Use in cats is controversial and many clinicians do not recommend its use in this species.

Diphenoxylathydrochlorid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diphenoxylathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 23)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29760 58
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15425 60
Alfa Chemistry 1-201-478-8534
1-516-927-0118 inquiry@alfa-chemistry.com United States 9935 60

3810-80-8(Diphenoxylathydrochlorid)Verwandte Suche:


  • Diphenoxylate for system suitability
  • Diphenoxylate hydrochloride solution
  • 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylesterhydrochl
  • ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotatemonohydrochloride
  • isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro
  • r1132
  • Diphenoxylate HCL (Subj To Narcotic Permit)
  • DIPHENOXYLATE HCL
  • DIPHENOXYLATE HYDROCHLORIDE
  • 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride
  • Diphenoxylate Hydrochloride CII (200 mg)
  • Diphenoxylate Hydrochloride CII (200 mg)I1D3390.998mg/mg(dr)
  • DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION
  • DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI
  • Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
  • 3810-80-8
  • C30H32N2O2HCl
  • Amines
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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