Diphenoxylathydrochlorid
Produkt Beschreibung
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- CAS-Nr.
- 3810-80-8
- Bezeichnung:
- Diphenoxylathydrochlorid
- Englisch Name:
- DIPHENOXYLATE HYDROCHLORIDE
- Synonyma:
- r1132;DIPHENOXYLATE HCL;DIPHENOXYLATE HYDROCHLORIDE;Diphenoxylate hydrochloride solution;Diphenoxylate for system suitability;Diphenoxylate Hydrochloride CII (200 mg);Diphenoxylate HCL (Subj To Narcotic Permit);DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION;DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI;Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
- CBNumber:
- CB6305387
- Summenformel:
- C30H33ClN2O2
- Molgewicht:
- 489.05
- MOL-Datei:
- 3810-80-8.mol
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Diphenoxylathydrochlorid Eigenschaften
- Schmelzpunkt:
- 220.5-222°
- storage temp.
- -20°C
- Löslichkeit
- Very slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in ethanol (96 per cent).
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| RIDADR |
1544 |
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| HazardClass |
6.1(b) |
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| PackingGroup |
III |
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| HS Code |
2933330000 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizität oral |
Kategorie 3 |
Achtung |
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P264, P270, P301+P310, P321, P330,P405, P501 |
| H317 |
Kann allergische Hautreaktionen verursachen. |
Sensibilisierung der Haut |
Kategorie 1A |
Warnung |
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P261, P272, P280, P302+P352,P333+P313, P321, P363, P501 |
| H334 |
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. |
Sensibilisierung der Atemwege |
Kategorie 1 |
Achtung |
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P261, P285, P304+P341, P342+P311,P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P284 |
Atemschutz tragen. |
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Diphenoxylathydrochlorid Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White or almost white, crystalline powder.
Originator
Lomotil,Searle,US,1960
Verwenden
Antiperistaltic; antidiarrheal.
Controlled substance (opiate).
Definition
ChEBI: The hydrochloride salt of diphenoxylate.
Manufacturing Process
A mixture of 23 parts of the ethyl ester of 4-phenylisonipecotic acid and 15
parts of 2,2-diphenyl-4-
omobutyronitrile in 19 parts of xylene is heated for
24 hours at 100-120°C and then cooled and filtered to remove the precipitate
of the hydro
omide of the ethyl ester of 4-phenylisonipecotic acid. The
filtrate is then extracted with dilute hydrochloric acid and the extract is
rendered alkaline by addition of concentrated aqueous potassium hydroxide
and extracted with ether. This ether extract is treated with gaseous hydrogen
chloride. The resulting precipitate is collected on a filter. The hydrochloride of
the ethyl ester of 2,2-diphenyl-4-(4'-carboxy-4'-phenyl-1'-
piperidino)butyronitrile thus obtained melts at about 220.5-222°C. See
meperidine hydrochloride for synthesis of 4-phenyl-isonipecotic acid ethyl
ester.
Therapeutic Function
Antidiarrheal
Veterinary Drugs and Treatments
Diphenoxylate is an opiate in combination with atropine in antidiarrheal
products used primarily in dogs; it also has antitussive
properties. Use in cats is controversial and many clinicians do not
recommend its use in this species.
Diphenoxylathydrochlorid Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Diphenoxylathydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 23)Lieferanten
3810-80-8(Diphenoxylathydrochlorid)Verwandte Suche:
- Diphenoxylate for system suitability
- Diphenoxylate hydrochloride solution
- 1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecoticacidethylesterhydrochl
- ethyl1-(3-cyano-3,3-diphenylpropyl)-4-phenylisonipecotatemonohydrochloride
- isonipecoticacid,1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-,ethylester,hydro
- r1132
- Diphenoxylate HCL (Subj To Narcotic Permit)
- DIPHENOXYLATE HCL
- DIPHENOXYLATE HYDROCHLORIDE
- 4-Piperidinecarboxylic acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, ethyl ester, monohydrochloride
- Diphenoxylate Hydrochloride CII (200 mg)
- Diphenoxylate Hydrochloride CII (200 mg)I1D3390.998mg/mg(dr)
- DIPHENOXYLATE HYDROCHLORIDE METHANOL SOL UTION
- DIPHENOXYLATE HYDROCHLORIDE ANTIPERISTAL TIC, ANTI
- Diphenoxylate Hydrochloride (1.0 mg/ml in Methanol)
- 3810-80-8
- C30H32N2O2HCl
- Amines
- Aromatics
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
