Ensartinib dihydrochloride
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- CAS-Nr.
- 2137030-98-7
- Englisch Name:
- Ensartinib dihydrochloride
- Synonyma:
- Ensartinib 2HCl;X-396 hydrochloride;X-396 dihydrochloride;Ensartinib hydrochloride;Ensartinib dihydrochloride;Ensartinib hydrochloride ( X396);Ensartinib (X-396) dihydrochloride;Ensartinib hydrochloride, 10 mM in DMSO;Ensartinib hydrochloride (X-396 hydrochloride);6-Amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3S,5R)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide hydrochloride
- CBNumber:
- CB64189028
- Summenformel:
- C26H28Cl3FN6O3
- Molgewicht:
- 597.9
- MOL-Datei:
- 2137030-98-7.mol
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Ensartinib dihydrochloride Eigenschaften
- storage temp.
- 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months).
- Aggregatzustand
- solid
- Farbe
- white
- Wasserlöslichkeit
- Water : 5 mg/mL (7.88 mM)
- InChIKey
- IERUINQRGJAECT-ISUJJMBGSA-N
Sicherheit
Ensartinib dihydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ensartinib
HCl is the salt form of Ensartinib, an orally available small molecule
inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase
(ALK) with potential antineoplastic activity. Upon oral administration,
X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK
point mutation variants. Inhibition of ALK leads to the disruption of
ALK-mediated signaling and eventually inhibits tumor cell growth in
ALK-expressing tumor cells. ALK belongs to the insulin receptor
superfamily and plays an important role in nervous system development.
Indications
Ensartinib dihydrochloride is mainly used to treat patients with ALK-positive non-small cell lung cancer (NSCLC).
Ensartinib dihydrochloride Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ensartinib dihydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 39)Lieferanten
- Ensartinib dihydrochloride
- Ensartinib hydrochloride
- X-396 hydrochloride
- Ensartinib hydrochloride ( X396)
- X-396 dihydrochloride
- Ensartinib,X396,Cluster of differentiation 246,X 396,Inhibitor,CD246,Anaplastic lymphoma kinase (ALK),Anaplastic lymphoma kinase,c-Met/HGFR,ALK tyrosine kinase receptor,Ensartinib hydrochloride,inhibit,X-396
- Ensartinib 2HCl
- Ensartinib (X-396) dihydrochloride
- 6-Amino-5-((R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-N-(4-((3S,5R)-3,5-dimethylpiperazine-1-carbonyl)phenyl)pyridazine-3-carboxamide hydrochloride
- Ensartinib hydrochloride, 10 mM in DMSO
- Ensartinib hydrochloride (X-396 hydrochloride)
- 2137030-98-7
- APIS
