Anti-KI-67 antibody, Rabbit monoclonal Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-KI-67 antibody, Rabbit monoclonal has been used in immunohistochemistry.
Allgemeine Beschreibung
The gene marker of proliferation Ki-67 (MKI67), spanning 15 exons, is mapped to human chromosome 10q26.2. The encoded protein contains phosphopeptide-binding forkhead-associated (FHA) domain and a protein phosphatase 1 (PP1)-binding site at N- terminal. It possesses 16 tandem repeats at central region and leucine and arginine (LR) pairs at C- terminal end.
Biochem/physiol Actions
Marker of proliferation Ki-67 (MKI67), which is a part of the mitotic chromosome periphery, functions as a biological surfactant to maintain individual mitotic chromosomes dispersed in the cytoplasm after nuclear envelope disassembly. Ki-67 is a vital prognostic marker in breast and prostate cancer. Expression of the encoded protein is associated with cell-proliferation rate. Ki-67 is expressed at all active phases of the cell cycle (G (1), S, G (2), and mitosis), except resting cells (G (0)). Therefore, this protein is considered to be a potent cell proliferation marker.
Anti-KI-67 antibody, Rabbit monoclonal Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
