2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Struktur
104121-92-8
CAS-Nr.
104121-92-8
Englisch Name:
2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Synonyma:
ED-71;Idecalcitol;Eldecalcitol;El calciditol;Eldecalcitol CRS;Aidit, calcitriol;Eldecalcitol(ED-71);2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3;1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3;104121-92-8 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
CBNumber:
CB71319007
Summenformel:
C30H50O5
Molgewicht:
490.71
MOL-Datei:
104121-92-8.mol

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Eigenschaften

Schmelzpunkt:
126-128℃
Siedepunkt:
655.7±55.0 °C(Predicted)
Dichte
1.10
storage temp. 
Store at -20°C
Löslichkeit
Soluble in DMSO
Aggregatzustand
Powder
pka
13.80±0.60(Predicted)
InChIKey
FZEXGDDBXLBRTD-AYIMTCTASA-N
SMILES
[C@@H]1(O)C/C(=C/C=C2\CCC[C@@]3(C)[C@@]\2([H])CC[C@@H]3[C@H](C)CCCC(O)(C)C)/C(=C)[C@@H](O)[C@@H]1OCCCO

Sicherheit

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.

Verwenden

Eldecalcitol is a derivative of vitamin D3 (V676045) which is the vitamin that mediates intestinal calcium absorbtion, bone calcium metabolism and probably, muscle activity.

Definition

ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.

Clinical Use

Eldecalcitol is a vitamin D3 analog approved in Japan for the treatment of osteoporosis. Itwasdiscoveredby Chugai and co-developed with Taisho. Eldecalcitol, a hormonally active calcitrol analog, regulates calcium and bone metabolism. The drug was approved on the basis of results from randomized, double-blinded, parallelgroup, phase III studies taking place over three years that showed eldecalcitol to significantly lower incidence of new vertebral fractures compared to those receiving the comparator drug alfacalcidol. Discovery and SAR studies of vitamin D3 analogs leading to the identification of eldecalcitol have been reported. In addition, multiple syntheses, including parallel approaches, have been reported in publications and patents.

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 190)Lieferanten
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Hangzhou ICH Biofarm Co., Ltd
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Capot Chemical Co.,Ltd.
571-85586718 +8613336195806
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+86-371-66670886
info@dakenam.com China 15928 58
Henan Tianfu Chemical Co.,Ltd.
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info@tianfuchem.com China 21691 55
career henan chemical co
+86-0371-86658258
sales@coreychem.com China 29914 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
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BOC Sciences
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Chongqing Chemdad Co., Ltd
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Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3586 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
sean.lv@synzest.com China 323 58

  • 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
  • Eldecalcitol
  • ED-71
  • (1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
  • 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3
  • Eldecalcitol(ED-71)
  • 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3
  • (1S,2S,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
  • El calciditol
  • Eldecalcitol {2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3}
  • 1,3-Cyclohexanediol, 2-(3-hydroxypropoxy)-4-methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-5-hydroxy-1,5-dimethylhexyl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,2R,3R,5Z)-
  • (1R,2R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-2-(3-hydroxypropoxy)-4-methylidenecyclohexane-1,3-diol
  • 104121-92-8 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
  • (1R,2R,3R,Z)-5-((E)-2-((1R,3aS,7aR)-1-((R)-6-Hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
  • Eldecalcitol CRS
  • Aidit, calcitriol
  • Idecalcitol
  • 104121-92-8
  • 04121-92-8
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