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2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Produkt Beschreibung

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Struktur
104121-92-8
CAS-Nr.
104121-92-8
Englisch Name:
2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Synonyma:
ED-71;Eldecalcitol;Eldecalcitol(ED-71);2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3;1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3;2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3;Eldecalcitol {2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3};(1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
CBNumber:
CB71319007
Summenformel:
C30H50O5
Molgewicht:
0
MOL-Datei:
104121-92-8.mol

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Eigenschaften

Schmelzpunkt:
126-128℃
Dichte
1.10

Sicherheit

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Eldecalcitol (Edirol) was approved in January 2011 by the Japanese Ministry of Health, Labor, and Welfare for the treatment of osteoporosis. Because of vitamin D’s central role in the bone health, vitamin D and analogs of vitamin D have been used to treat patients diagnosed with osteoporosis. Eldecalcitol is an analog of the active form of vitamin D, calcitriol, in which the lower cyclohexane ring contains a hydroxypropyl group. The synthesis of eldecalcitol involves the assembly of two units, a fully protected (3S,4S,5R)-oct-1-en-7-yne-3,4,5-triol and a fused bicyclic system, (R)-6- ((1R,3aR,7aR,E)-4-(bromomethylene)-7a-methyloctahydro-1H-inden-1- yl)-2-methylheptan-2-ol, through a Diels-Alder reaction to give fully protected eldecalcitol. The hydroxyl groups are then deprotected to give the parent molecule. Eldecalcitol binds to the vitaminDreceptor 2.7-fold more potently than calcitriol, while only weakly inhibiting serum parathyroid hormone.

Originator

Chugai Pharmaceutical/Roche (Japan)

Definition

ChEBI: A hydroxycalciol that is calcitriol with a 3-hydroxypropoxy group at position 2.

Trademarks

Edirol

2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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  • 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
  • Eldecalcitol
  • ED-71
  • Eldecalcitol(ED-71)
  • 2.beta.-(3-Hydroxypropoxy)-1.alpha.,25-dihydroxyvitaMin D3
  • (1R,Z)-5-((E)-2-((1R,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-2-(3-hydroxypropoxy)-4-methylenecyclohexane-1,3-diol
  • 1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3
  • Eldecalcitol {2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3}
  • 104121-92-8
  • 04121-92-8
  • -
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