4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Struktur
461432-23-5
CAS-Nr.
461432-23-5
Englisch Name:
4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
Synonyma:
4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene;Dapagliflozin Bromo impurity;Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-;Dapagliflozin-13;Dapaglifozin DAP Bromo;5-broMo-2-chloro-4’Dapagliflozin Impurity 15;4-(Dibenzofuranyl)boronic;Dapagliflozin Impurity 82;Dapagliflozin Intermediate 1
CBNumber:
CB71456759
Summenformel:
C15H14BrClO
Molgewicht:
325.63
MOL-Datei:
461432-23-5.mol

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Eigenschaften

Siedepunkt:
393.0±32.0 °C(Predicted)
Dichte
1.371±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
Löslichkeit
Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Low-Melting Solid
Farbe
White to Off-White
Stabilität:
Stable under recommended storage conditions., Stable Under Recommended Storage C
InChI
InChI=1S/C15H14BrClO/c1-2-18-14-6-3-11(4-7-14)9-12-10-13(16)5-8-15(12)17/h3-8,10H,2,9H2,1H3
InChIKey
ZUNCHZBITMUSRD-UHFFFAOYSA-N
SMILES
C1(Cl)=CC=C(Br)C=C1CC1=CC=C(OCC)C=C1
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
HS Code  2909309090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

5-Bromo-2-chloro-4'-ethoxydiphenylmethane is a hydrocarbon derivative and can be used as an intermediate for dapagliflozin.

Synthese

Oxalyl chloride (0.8 mL) was added to a solution of 5-bromo-2-chlorobenzoic acid (2 g) in dichloromethane (20 mL) and dimethylformamide (0.2 mL) under a nitrogen atmosphere. The reaction mixture was stirred for one hour at 25° C to 30° C. After completion of the reaction, the reaction mixture was concentrated under a vacuum at 40° C to 45° C. to obtain an oily residue. The oily residue was dissolved in dichloromethane (20 mL) and cooled to 0° C. To this solution, phenol (1.1 mL) and aluminium chloride (2.3 g) were added at 0° C. to 5° C. The reaction mixture was stirred at 0° C to 5° C for 2 hours. The reaction mixture was allowed to warm to about 20° C, and triethylsilane (3.4 mL) was slowly added to it at the same temperature. The reaction mixture was stirred for about 36 hours from 20° C to 25° C. After completion of the reaction, 4-bromo-1-chloro-2-(4-ethoxybenzyl)benzene was obtained by further purification.

4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 546)Lieferanten
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Shanghai Rochi Pharmaceutical Co.,Ltd.
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+86-16632316109
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+8617756083858
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461432-23-5()Verwandte Suche:


  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane
  • 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • Dapagliflozin Intermediate 1
  • 4-broMo-1-chloro-2-[(4-ethoxyphenyl)Methyl]-
  • 2-(4-Methoxybenzyl)-4-broMo-1-chlorobenzene
  • 1-(5-broMo-2-chlorobenzyl)-4-ethoxybenzene
  • 5-broMo-2-chloro-4&rsquo
  • Dapagliflozin Intermediate II
  • Dapagliflozin Intermediate 2
  • 5-bromo-2-chloro-4'-ethoxydiphenylmethane###461432-23-5
  • (5-bromo-2-chlorobenzyl)-4-ethoxybenzene
  • 4-(5-Brom-2-chlorbenzyl)phenyl-ethylether
  • Dapagliflozin Impurity 15
  • Dapagliflozin-13
  • 4-(Dibenzofuranyl)boronic
  • 4-(5-Bromo-2-chlorobenzy)phenylethyl ester
  • Dapagliflozin Impurity 82
  • 4-Bromo-1-chloro-2-(4-ethoxybenzyl)
  • Dapagliflozin Despyranose Bromo Impurity
  • 4-Brom-1-chlor-2-(4-ethoxybenzyl)benzol
  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane ISO 9001:2015 REACH
  • 4-(3-((1-ethoxyethoxy)methyl)-4-bromophenoxy)benzonitrile
  • Supply 5-bromo-2-chloro-4'-ethoxydiphenylmethane
  • Dapaglifozin DAP Bromo
  • 5-bromo-2-chloro-4-ethoxydiphenylmethaneQ: What is 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the CAS Number of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What is the storage condition of 5-bromo-2-chloro-4-ethoxydiphenylmethane Q: What are the applications of 5-bromo-2-chloro-4-ethoxydiphenylmethane
  • Benzene, 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]-
  • Dapagliflozin Bromo impurity
  • 4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene
  • Dapagliflozin Intermediate/ 5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane
  • 4-(5- bromo -2- chlorobenzyl) phenethyl ether
  • 5-Bromo-2-chIoro-4’-ethoxydiphenyImethane
  • 4-Bromo-1-ChIoro 2-4-EthoxybenzyI-Benzene
  • 4-bromo-l-chloro-2-(4-ethoxybenzyl)benzene
  • 2-(4-ethoxybenzyl)-4-bromo-1-chloro benzene
  • 5-bromo-2-chloro-4’-ethoxydiphenylmethane, Or 4-(5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • (5-Bromo-2-chlorobenzyl)phenyl ethyl ether
  • 5-bromo-2-chloro-4'-ethoxydiphenylmethane
  • 6-bromo-2-chloro-4’-ethoxydiphenylmethane
  • 4-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene
  • 461432-23-5
  • 61432-23-5
  • 100134-06-9
  • 9461432-23-5
  • C15H14BrClO
  • Halides
  • Phenyls & Phenyl-Het
  • 461432-23-5
  • ADVANCED INT.
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