Antibiotic 61477, Coxxistac

Antibiotic 61477, Coxxistac Struktur
CAS-Nr.
Englisch Name:
Antibiotic 61477, Coxxistac
Synonyma:
Antibiotic 61477, Coxxistac;Salinomycin, Ready Made Solution
CBNumber:
CB72892608
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Antibiotic 61477, Coxxistac Eigenschaften

Flammpunkt:
87 °C
storage temp. 
-20°C
Löslichkeit
DMSO: soluble

Sicherheit

RIDADR  NA 1993 / PGIII
WGK Germany  2

Antibiotic 61477, Coxxistac Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

Allgemeine Beschreibung

Chemical structure: polyether

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Antibiotic 61477, Coxxistac Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Antibiotic 61477, Coxxistac Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 2)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

  • Antibiotic 61477, Coxxistac
  • Salinomycin, Ready Made Solution
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