Antibiotic 61477, Coxxistac
- CAS No.
- Chemical Name:
- Antibiotic 61477, Coxxistac
- Synonyms
- Antibiotic 61477, Coxxistac;Salinomycin, Ready Made Solution
- CBNumber:
- CB72892608
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD25541652
- MOL File:
- Mol file
Antibiotic 61477, Coxxistac price More Price(1)
Antibiotic 61477, Coxxistac Chemical Properties,Uses,Production
Uses
Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.
General Description
Chemical structure: polyether
Biochem/physiol Actions
Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.
Antibiotic 61477, Coxxistac Preparation Products And Raw materials
Raw materials
Preparation Products
Antibiotic 61477, Coxxistac Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |