Antibiotic 61477, Coxxistac

CAS No.
Chemical Name:
Antibiotic 61477, Coxxistac
Synonyms
Antibiotic 61477, Coxxistac;Salinomycin, Ready Made Solution
CBNumber:
CB72892608
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD25541652
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

Antibiotic 61477, Coxxistac Properties

Flash point 87 °C
storage temp. -20°C
solubility DMSO: soluble

SAFETY

Risk and Safety Statements

RIDADR  NA 1993 / PGIII
WGK Germany  2

Antibiotic 61477, Coxxistac price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S6201 Salinomycin, Ready Made Solution from Streptomyces albus, ≥98% (HPLC) 500μl $79.5 2024-03-01 Buy
Product number Packaging Price Buy
S6201 500μl $79.5 Buy

Antibiotic 61477, Coxxistac Chemical Properties,Uses,Production

Uses

Salinomycin, Ready Made Solution has been used as an inhibitor of endocytosis in primary pancreatic tumor cells. It has also been used in sequential treatment of cancer cells to study resistance.

General Description

Chemical structure: polyether

Biochem/physiol Actions

Salinomycin is a monocarboxylic polyether antibiotic with unique tricyclic spiroketal ring systems and an unsaturated six-membered ring in the molecule. Salinomycin has antimicrobial and anticoccidial activities. It is an alkali ion carrier with affinity for cations and preference for K+ over other monovalent and divalent cations. Polyether antibiotics (also called carboxylic ionophores) facilitate bidirectional ion flux through the lipid barrier of membranes causing interference with natural ion transport systems both in prokaryotic and eukaryotic cells. Tumor cells express elevated levels of various types of K+ channels, which enhances cell proliferation. Thus, drugs acting as channel blockers inhibit cell proliferation. Being a highly selective potassium ionophore, salinomycin may interfere with potassium channels function in cancer stem cells (CSCs). Established cancer therapies may fail because they kill the bulk tumor cells, but do not eliminate CSCs. Studies indicate that Salinomycin selectively eradicates breast CSCs. Salinomycin may eliminate CSCs by inducing their differentiation. salinomycin suppresses the metastatic migration of 4T1 cells to the lungs.

Antibiotic 61477, Coxxistac Preparation Products And Raw materials

Raw materials

Preparation Products

Antibiotic 61477, Coxxistac Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Supplier Advantage
Sigma-Aldrich 80
Antibiotic 61477, Coxxistac Salinomycin, Ready Made Solution