ANHYDROTETRACYCLINE HYDROCHLORIDE
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- CAS-Nr.
- 13803-65-1
- Englisch Name:
- ANHYDROTETRACYCLINE HYDROCHLORIDE
- Synonyma:
- AnhydrotetracyclineHCl;Tetracycline Anhydro HCl;Aureomycin EP impurity J;Anhydrotetracycline HCl, EvoPure;ANHYDROTETRACYCLINE HYDROCHLORIDE;5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE;Anhydrotetracycline hydrochloride CRS;Anhydrotetracycline hydrochloride ,97%;ANHYDROTETRACYCLINE HYDROCHLORIDE USP/EP/BP;Lymecycline Impurity 3（Lymecycline EP Impurity C）
- CBNumber:
- CB7438626
- Summenformel:
- C22H23ClN2O7
- Molgewicht:
- 462.88
- MOL-Datei:
- 13803-65-1.mol
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ANHYDROTETRACYCLINE HYDROCHLORIDE Eigenschaften
- Schmelzpunkt:
- 223 °C
- RTECS-Nr.
- QI7860000
- storage temp.
- Refrigerator
- Löslichkeit
- Soluble in ethanol, DMSO, or DMF
- Aggregatzustand
- Powder
- Farbe
- Yellow to bright yellow
- Sensitive
- Moisture Sensitive
- BRN
- 4228856
- Stabilität:
- Hygroscopic
- EPA chemische Informationen
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, hydrochloride (1:1), (4S,4aS,12aS)- (13803-65-1)
ANHYDROTETRACYCLINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
R-Sätze Betriebsanweisung:
R63:Kann das Kind im Mutterleib möglicherweise schädigen.
R36:Reizt die Augen.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Beschreibung
The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression. Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-
repressor to bind tetO and block transcription. Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-
fold more strongly than Tet. Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet, so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-
fold above the dose that alters transcription through TetR.
Chemische Eigenschaften
yellow to bright yellow powder
Verwenden
Anhydrotetracycline hydrochloride is a salt of a degradation product of tetracycline, formed by dehydration at the C6 position under acidic conditions to aromatise the B ring. Anhydrotetracycline is an important standard for monitoring tetracycline stability. Although the degradation is associated with a loss of antibiotic activity, anhydrotetracycline is considered biologically active and is thought responsible for aspects of tetracycline toxicity.
ANHYDROTETRACYCLINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ANHYDROTETRACYCLINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 105)Lieferanten
13803-65-1()Verwandte Suche:
1,3-Dimethylnaphthalin
1,2-Dimethylnaphthalin
2-Acetyl-1,2,3,4-tetrahydronaphthalin-1-on
2-Hydroxy-2-methylpropiophenon
Naphthalin-2-ethanol
1,2,3,4-Tetrahydro-2-methylnaphthalin-1-on
Tetracyclin
1'-Hydroxy-2'-acetonaphthon
2,3-Dimethylnaphthalin
3,4-Dihydro-5-methylnaphthalin-1(2H)-on
1,2,3-Trimethylnaphthalin
- ANHYDROTETRACYCLINE HYDROCHLORIDE
- AnhydrotetracyclineHCl
- Anhydrotetracycline hydrochloride, 'can be used as a secondary standard'
- 2-Naphthacenecarboxamide, 4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-, monohydrochloride, (4S,4aS,12aS)-
- 5A,6-ANHYDROTETRACYCLINEHYDROCHLORIDE
- Anhydrotetracycline hydrochloride,'can be used as secondary standard.'
- Anhydrotetracycline hydrochloride ,97%
- (4S,4AS,12AS)-4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-2-NAPHTHACENECARBOXAMIDE MONOHYDROCHLORIDE
- (4S,4aS,12aS)-4-(DiMethylaMino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-Methyl-1,12-dioxo-2-naphthacenecarboxaMide Hydrochloride
- Lymecycline Impurity 3（Lymecycline EP Impurity C）
- Anhydrotetracycline hydrochloride CRS
- Tetracycline Anhydro HCl
- Aureomycin EP impurity J
- ANHYDROTETRACYCLINE HYDROCHLORIDE USP/EP/BP
- Anhydrotetracycline HydrochlorideQ: What is
Anhydrotetracycline Hydrochloride Q: What is the CAS Number of
Anhydrotetracycline Hydrochloride Q: What is the storage condition of
Anhydrotetracycline Hydrochloride Q: What are the applications of
Anhydrotetracycline Hydrochloride
- Anhydrotetracycline Hydrochloride ((4S ,4aS ,12aS )-4-(Dimethylamino)-3,10,11,12a-tetrahydroxy-6-me (1035708)
- (4S,4aS,12aS)-4-(dimethylamino)-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-1,4,4a,5,12,12a-hexahydrotetracene-2-carboxamide (anhydrotetracycline)
- Chlortetracycline Hydrochloride EP Impurity J as Hydrochloride
- Tetracycline Hydrochloride EP Impurity C as Hydrochloride
- 2-Naphthacenecarboxamide,4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-,hydrochloride (1:1), (4S,4aS,12aS)-
- Anhydrotetracycline HCl, EvoPure
- 13803-65-1
- Drug Analogues
- Intermediates & Fine Chemicals
- Pharmaceuticals
