PIROHEPTINE

PIROHEPTINE Struktur
16378-21-5
CAS-Nr.
16378-21-5
Englisch Name:
PIROHEPTINE
Synonyma:
PIROHEPTINE;3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-1-ethyl-2-methylpyrrolidine;3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine;1-Ethyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-2-methylpyrrolidine;Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-
CBNumber:
CB81011586
Summenformel:
C22H25N
Molgewicht:
303.44
MOL-Datei:
16378-21-5.mol

PIROHEPTINE Eigenschaften

Siedepunkt:
bp4 167°
Dichte
0.9930 (rough estimate)
Brechungsindex
1.4900 (estimate)
pka
8.55±0.40(Predicted)

Sicherheit

PIROHEPTINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator

Trimol,Fujisawa ,Japan ,1974

Manufacturing Process

(1) To 3.8 g of 2-methyl-3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5ylidene)-1-pyrroline, there were added 8 g of ethyl iodide. This mixture was placed into a closed vessel and heated at 80°C in a water-bath for one hour. After completing the reaction, the reaction mixture was cooled and the unreacted ethyl iodide was distilled off to yield 5.5 g of 1-ethyl-2methyl-3(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-1-pyrrolinium iodide in the form of yellow crystals. These crystals were recrystallized from a mixture of acetone and ether to yield yellow needles of the melting point 223°C.
(2)1-Ethyl-2-methyl-3-(10,11)-dihydro-5H-dibenzo[a,d]cycloheptene-5ylidene)-1-pyrroliniumiodide (4.7 g) was dissolved in 7 cc of methanol. To this solution there were added 1.4 g of sodium boron hydride within about 80 minutes with stirring and stirring of the solution was continued for two hours to complete the reaction. The reaction mixture was acidified with 10% aqueous hydrochloric acid solution and then the methanol was distilled off. The residual solution was alkalized with 20% aqueous sodium hydroxide solution and extracted with ether. The ether layer was dried over magnesium sulfate and the ether was distilled off. The resulting residue was further distilled under reduced pressure to yield 2.0 g of 1-ethyl-2-methyl-3-(10,11)dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)pyrrolidine (boiling point 167°C/4 mm Hg.).

Therapeutic Function

Antiparkinsonian

PIROHEPTINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PIROHEPTINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 8)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63711 58
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14059 65
BOC Sciences 16314854226
info@bocsci.com United States 9926 65

16378-21-5()Verwandte Suche:


  • PIROHEPTINE
  • 1-Ethyl-3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-2-methylpyrrolidine
  • 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine
  • 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-1-ethyl-2-methylpyrrolidine
  • Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-
  • 16378-21-5
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