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MK-1775

MK-1775 Struktur
955365-80-7
CAS-Nr.
955365-80-7
Englisch Name:
MK-1775
Synonyma:
AZD1775;CS-605;101254;MK-1775;MK-1175;MK-1755;Adavosertib);MK-1775, >=98%;MK-1775,MK1775;MK-1775, AZD1775,
CBNumber:
CB82514921
Summenformel:
C27H32N8O2
Molgewicht:
500.6
MOL-Datei:
955365-80-7.mol
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MK-1775 Eigenschaften

Schmelzpunkt:
179-181°C
Siedepunkt:
723.8±70.0 °C(Predicted)
Dichte
1.292
storage temp. 
-20°C
Löslichkeit
Soluble in DMSO (70 mg/ml)
Aggregatzustand
solid
pka
13.27±0.29(Predicted)
Farbe
Yellow
Stabilität:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserklärung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitsschädlich bei Verschlucken. Akute Toxizität oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

MK-1775 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

MK-1775 is a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. MK-1775 is a type of biological therapy. It is a cancer growth blocker. It stops signals that cancer cells use to divide and grow. MK-1775 has been used in trials studying the treatment of LYMPHOMA, Neoplasms, Ovarian Cancer, Tongue Carcinoma, and Adult Glioblastoma, among others.

Verwenden

MK 1775 is used in biological studies for the abrogation of G2/M checkpoint through WEE1 inhibition in combination with chemotherapy as a promising therapeutic approach for mesothelioma.

MK-1775 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

6-BROMOPYRIDINE-2-CARBOXYLIC ACID METHYL ESTER 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one 4-(4-Methylpiperazino)aniline 2-allyl-6-(Methylthio)-1H-pyrazolo[3,4-d]pyriMidin-3(2H)-one 2-(6-broMopyridin-2-yl)propan-2-ol

Downstream Produkte

MK-1775 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 239)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070
product@chemlin.com.cn CHINA 3012 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32480 60
Biochempartner 		0086-13720134139
candy@biochempartner.com CHINA 967 58
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 6992 58
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22968 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49390 58
career henan chemical co 		+86-0371-86658258 15093356674;
 factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Qiuxian Baitai New Material Co., LTD 		+8618330912755
 sale2@hbyalin.com China 1677 58
  • 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
  • MK-1775
  • MK-1775,MK1775
  • 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1,2-dihydropyrazolo[3,4-d]pyrimidin-3-one
  • 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one MK 1775
  • MK 1775 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
  • MK-1775, >=98%
  • MK-1175
  • 3H-Pyrazolo[3,4-d]pyrimidin-3-one, 1,2-dihydro-1-[6-(1-hydroxy-1-methylethyl)-2-pyridinyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-2-(2-propen-1-yl)-
  • MK-1775, AZD1775,
  • 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(4-(4-methylpiperazin-1-yl)phenylamino)-1H-
  • MK1775;AZD-1775;AZD1775;AZD 1775;MK 1775
  • CS-605
  • 101254
  • 2-ALLYL-1-(6-(2-HYDROXYPROPAN-2-YL)PYRIDIN-2-YL)-6-(4-(4-METHYLPIPERAZIN-1-YL)PHENYLAMINO)-1H-PYRAZO
  • Adavosertib)
  • 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one
  • Adavosertib (MK-1775)
  • MK-1775(955365-80-7)
  • MK-1775(AZD1775,Adavosertib)
  • AZD1775;MK-1775;MK1775
  • MK-1775,Adavosertib
  • 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)pyrazolo[3,4-d]pyrimidin-3-one
  • 2-allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one
  • MK-1775 ISO 9001：2015 REACH
  • 2-Allyl-1-[6-(2-hydroxy-2-propyl)-2-pyridyl]-6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]pyrazolo[3,4-d]pyrimidin-3(2H)-one
  • Adavosertib (AZD-1775
  • 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiper...
  • AZD1775
  • MK-1755
  • AZD-1775,AZD 1775,MK1775,MK 1775,Adavosertib,Wee1,inhibit,Inhibitor
  • 955365-80-7
  • Inhibitors
  • Other APIs
  • API
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