TH287

1609960-30-6

CAS-Nr.: 1609960-30-6

Englisch Name:: TH287

Synonyma:: TH287;CS-1671;Centicin;Septigen;TH287, >98%;TH287;TH-287;Oksitselanim;TH287 hydrochloride;6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine;6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine

CBNumber:: CB82749064

Summenformel:: C11H10Cl2N4

Molgewicht:: 269.13

MOL-Datei:: 1609960-30-6.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 94

TH287 Eigenschaften

Siedepunkt:: 512.2±60.0 °C(Predicted)

Dichte: 1.440±0.06 g/cm3(Predicted)

storage temp.: 2-8°C

Löslichkeit: DMSO: soluble5mg/mL, clear (warmed)

pka: 5.91±0.10(Predicted)

Aggregatzustand: powder

Farbe: white to beige

Sicherheit

Risiko- und Sicherheitserklärung
Gefahreninformationscode (GHS)

Kennzeichnung gefährlicher	Xn
R-Sätze:	22-41
S-Sätze:	26-39
WGK Germany	3

Bildanzeige (GHS)

Alarmwort

Achtung

Gefahrenhinweise

Code	Gefahrenhinweise	Gefahrenklasse	Abteilung	Alarmwort	Symbol	P-Code
H302	Gesundheitsschädlich bei Verschlucken.	Akute Toxizität oral	Kategorie 4	Warnung	src="/GHS07.jpg" width="20" height="20" />	P264, P270, P301+P312, P330, P501
H318	Verursacht schwere Augenschäden.	Schwere Augenschädigung	Kategorie 1	Achtung	src="/GHS05.jpg" width="20" height="20" />	P280, P305+P351+P338, P310

Sicherheit

P280

Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

TH287 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Human mutT homolog (MTH1) is a nucleotide pool sanitizing enzyme that cleaves oxidized nucleotides (dNTPs) to prevent incorporation of damaged bases during DNA replication. Cancer cells rely on MTH1 activity in order to avoid cell death. TH287 is an MTH1 inhibitor (IC₅₀ = 0.8 nM) that selectively kills cancer cell lines (IC₅₀s = 0.8-3.06 μM) without significant cytotoxicity towards primary or immortalized cells (IC₅₀s = ≥20 μM). At up to 100 μM it does not show significant effect towards the related nudix hydrolase protein family members MTH2, NUDT5, NUDT12, NUDT14, and NUDT16, as well as other proteins with known nucleoside triphosphate pyrophosphatase activity (dCTPase, dUTPase, and ITPA).

Verwenden

6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine is known to possess antitumor effects and nanomolar MTH1-inhibitory activity in vitro for cancer cell survival.

TH287 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,3-Dichlorophenylboronic acid NSC36831 4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine Methylamin, gasförmig

Downstream Produkte

TH287 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 94)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58

TH287 hydrochloride
TH287
6-(2,3-dichlorophenyl)-N4-methylpyrimidine-2,4-diamine
6-(2,3-Dichlorophenyl)-N4-methylpyrimidine-2,4-diamine hydrochloride
6-(2,3-Dichlorophenyl)-N4-methyl-2,4-pyrimidinediamine
TH287;TH-287
CS-1671
TH287, >98%
2,4-Pyrimidinediamine, 6-(2,3-dichlorophenyl)-N4-methyl-
6-(2,3-Dichlorophenyl)-4-N-methylpyrimidine-2,4-diamine
Centicin
Oksitselanim
Septigen
1609960-30-6
Inhibitors