MMP-12 Inhibitor Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC
50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC
50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC
50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC
50 >5 μM), TACE (IC
50 >25 μM), and MMP-1/7 (IC
50 >6 μM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice
in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).
MMP-12 Inhibitor Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
