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MMP-12 Inhibitor

MMP-12 Inhibitor Structure
MMP-12 Inhibitor structure
CAS No.
1258003-93-8
Chemical Name:
MMP-12 Inhibitor
Synonyms
MMP-12 Inhibitor;MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem;D-Valine, N-[[8-[(methoxycarbonyl)amino]-3-dibenzofuranyl]sulfonyl]-
CBNumber:
CB83121492
Molecular Formula:
C19H20N2O7S
Molecular Weight:
420.44
MDL Number:
MOL File:
1258003-93-8.mol
MSDS File:
SDS
Last updated:2023-04-23 13:52:06
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MMP-12 Inhibitor Properties

Density 1.440±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
form Off-white solid
pka 3.37±0.10(Predicted)

MMP-12 Inhibitor price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 444291 MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem
The MMP-12 Inhibitor, MMP408, also referenced under CAS 1258003-93-8, controls the biological activity of MMP-12. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. 		1258003-93-8 5mg $230 2024-03-01 Buy
Product number Packaging Price Buy
444291 5mg $230 Buy

MMP-12 Inhibitor Chemical Properties,Uses,Production

General Description

A dibenzofuranylsulfanamido-valine compound that acts as a potent, active site zinc-targeting, MMP-12-selective inhibitor (IC50 = 2 nM against human MMP-12) with much weaker activity against MMP-12 from mouse/rat/sheep species (IC50 = 160, 320 and 22.3 nM, respectively) or human MMP-3/13/14 (IC50 = 351, 120 and 1100 nM , respectively), and practically ineffective toward human Agg-1/2 (IC50 >5 μM), TACE (IC50 >25 μM), and MMP-1/7 (IC50 >6 μM). MMP408 is orally active in mice and shown to effectively alleviate rhMMP-12-induced pulmonary inflammatory response in mice in vivo by more than 50% (5 mg/kg, p.o., b.i.d.).

MMP-12 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

MMP-12 Inhibitor Suppliers

Global( 8)Suppliers
Supplier Tel Email Country ProdList Advantage
Alpha Biopharmaceuticals Co., Ltd 		+86-15542445688 sales@alabiochem.com China 884 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439 sales@nextpeptide.com China 19915 58
Alabiochem Tech.Co., Ltd. 0512-58900862 400-0707518 sales@alabiochem.com China 997 59
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Alabiotech Inc. 001-619-354-5251 sales@alabiotech-e.com United States 972 60
Alpha Biopharmaceuticals Co., Ltd 0411-39042497 sales@alphabiopharm.com China 1951 58
Nanjing Shizhou Biology Technology Co.,Ltd 025-85560043 15850508050 cindy.huang@synzest.com China 12007 58
Supplier Advantage
Alpha Biopharmaceuticals Co., Ltd 		58
Nextpeptide Inc 		58
Alabiochem Tech.Co., Ltd. 59
Sigma-Aldrich 80
Alabiotech Inc. 60
Alpha Biopharmaceuticals Co., Ltd 58
Nanjing Shizhou Biology Technology Co.,Ltd 58
MMP-12 Inhibitor MMP-12 Inhibitor, MMP408 - CAS 1258003-93-8 - Calbiochem D-Valine, N-[[8-[(methoxycarbonyl)amino]-3-dibenzofuranyl]sulfonyl]- 1258003-93-8