NS8593 HYDROCHLORIDE

NS8593 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NS 8593 is an inhibitory gating modifier of small-conductance calcium-activated potassium (K_Ca2/SK) channels (K_ds = 0.42, 0.6, and 0.73 μM for K_Ca2.1/SK1, K_Ca2.2/SK2, and K_Ca2.3/SK3, respectively, in the presence of calcium) that decreases the calcium sensitivity of SK channels. It is selective for K_Ca2/SK channels over intermediate- (K_Ca3.1/IK_Ca1) and large-conductance (BK) potassium channels at 10 μM. NS 8593 induces relaxation of potassium- or acetylcholine chloride-precontracted isolated tracheal rings from wild-type mice (IC₅₀s = 8.9 and 39.8 μM, respectively) or from mice in an ovalbumin-induced model of allergic asthma (IC₅₀s = 16.4 and 32.2 μM, respectively). It inhibits aerosolized acetylcholine chloride-induced increases in respiratory system resistance in mice when administered as an aerosol at a dose of 500 μM. NS 8593 (5 mg/kg) decreases the duration of burst-pacing-induced atrial fibrillation in normotensive and spontaneously hypertensive rats.

Verwenden

NS8593 hydrochloride has been used to study its effect on the growth of MDA-MB-231 cells (M.D. Anderson and metastasis breast cancer cells).

Biochem/physiol Actions

The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.

NS8593 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NS8593 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39035	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850	market18@leapchem.com	China	43339	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Shanghai Rechem science Co., Ltd.	021-31433387 15618786686	sales@rechemscience.com	China	2990	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51395	80
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4768	55
Shanghai YuanYe Biotechnology Co., Ltd.	021-61312847; 18021002903	3008007409@qq.com	China	71826	60
Shanghai SuperLan Chemcial Technique Centre	0-2022843681 15618226720	chaolaichem@foxmail.com	China	10410	58

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• NS8593 HYDROCHLORIDE
• : N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-1H-Benzimidazol-2-amine hydrochloride
• NS8593
• N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]-1H-benzimidazol-2-amine
• NS8593 HCl
• NS8593 hydrochloride,inhibit,NS8593,neurological,Ca2+,Inhibitor,hIK,SK1,SK2,KcsA,Potassium Channel,NS-8593,SK3,hBK,neurons,NS-8593 hydrochloride,dopaminergic,NS 8593,channel
• NS8593 hydrochloride, 10 mM in DMSO
• 875755-24-1