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(3α,16α)-Eburnamenin-14(15H)-on Produkt Beschreibung

(-)-EBURNAMONINE Struktur
4880-88-0
CAS-Nr.
4880-88-0
Bezeichnung:
(3α,16α)-Eburnamenin-14(15H)-on
Englisch Name:
(-)-EBURNAMONINE
Synonyma:
(-)-Vi;ch-846;eburnal;Cervoxan;VINCAMONE;vinburnine;cis-vincamone;eburnalritardo;l-eburnamonine;Vinburnine base
CBNumber:
CB9130995
Summenformel:
C19H22N2O
Molgewicht:
294.39
MOL-Datei:
4880-88-0.mol

(3α,16α)-Eburnamenin-14(15H)-on Eigenschaften

Schmelzpunkt:
174-177 °C(lit.)
alpha 
D25 -102° (chloroform) (Clauder); D -100° (c = 0.783 in chloroform) (Cartier)
Siedepunkt:
436.16°C (rough estimate)
Dichte
1.34
Brechungsindex
1.5600 (estimate)
storage temp. 
Sealed in dry,2-8°C
Aggregatzustand
White to slightly yellow crystalline powder.
pka
8.13±0.40(Predicted)
Merck 
13,3520
CAS Datenbank
4880-88-0(CAS DataBase Reference)

Sicherheit

S-Sätze: 22-24/25
WGK Germany  2
RTECS-Nr. YY8575570
8-10

(3α,16α)-Eburnamenin-14(15H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

white to slightly yellow crystalline powder

Originator

Euburnamonine ,Shanghai Lansheng Corporation

Verwenden

Cerebral vasodilatator

Manufacturing Process

200 g (0.087 moles) of cis-1-ethyl-1-(2'-hydroxy-2'-carboxyethyl)- 1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine were suspended in 100 ml of xylene. 12 g of supported silver carbonate (a silver carbonate-Celite reagent, containing 50% of silver carbonate) were added to the suspension, and the system was boiled for 8 hours under a nitrogen atmosphere, with constant stirring. Thereafter the hot solution was filtered, washed with 3 x 30 ml to 5% sodium carbonate solution, dried over magnesium sulfate, and evaporated under reduced pressure. 1.05 g of a solid residue, which was a mixture of racemic vincamone and racemic vincanol, was obtained. 40 ml of ethyl ether were added to the mixture, and the insoluble crystals were filtered off. The crystals were recrystallized from methanol, to yield 0.5 g of (+/-)- eburnamonine (vincamone). Yield: 29.5%. MP: 201°-202°C. The value was identical with the literature value (J. Mokry et aI.: CoII. Czech, Chem. Comm. 28, 1309, 1963). The etheral mother liquor was processed by preparative layer chromatography (adsorbent: Kieselgel PF 254+366 , developing agent: a 14:2 mixture of benzene and methanol). The obtained substance was recrystallized from ether to yield 0.2 g (16%) of (+/-)-vincanol (eburnamine). MP: 163-164°C, under decomposition. The IR spectrum of the obtained substance was identical with that of the authentic sample.
Resolution of (+/-)-vincamone:
10.0 g (0.0342 moles) of (+/-)-vincamone and 12.2 g (0.0342 moles) of (-)- dibenzoyl tartaric acid were dissolved in 150 ml of dichloromethane, the solution was seeded with crystalline (-)-vincamone-(-)-dibenzoyl-tartarate, and the mixture was left to stand. The separated crystals were filtered off, dissolved in dimethylformamide, and the pH of the solution was adjusted to 9 with aqueous ammonia. The separated substance was filtered off, washed with water, and dried. This way 4.2 g (84%) of (-)-vincamone were obtained; MP: -176°C; α D 20 = -96°. The mother liquor of resolution was evaporated and (+)- vincamone was separeted as described above. The obtained substance had MP: 173°-176°C.; α D 20 = +96°.

Therapeutic Function

Cerebrotonic

(3α,16α)-Eburnamenin-14(15H)-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(3α,16α)-Eburnamenin-14(15H)-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 124)Lieferanten
Firmenname Telefon Fax E-Mail Land Produktkatalog Edge Rate
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
NanJing Spring & Autumn Biological Engineering CO., LTD.
0086 13815430202 0086 13815430202
sale02@cqherb.com CHINA 372 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 743 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
HENAN BON INDUSTRIAL CO.,LTD
0371-55170695
info@hnbon.com CHINA 26742 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29865 58
SIMAGCHEM CORP
13806087780 +86 13806087780
shaobowang@simagchem.com CHINA 17607 58
Kindchem(Nanjing)Co.,Ltd
18651653755 025-85281586
025-68661290 sales@kindchem.cn CHINA 513 58

4880-88-0((3α,16α)-Eburnamenin-14(15H)-on)Verwandte Suche:


  • (-)-eburnamonina
  • (-)-EBURNAMONINE
  • EBURNAMONINE, (-)-
  • VINCAMONE
  • (3alpha,16alpha)-eburnamenin-14(15H)-one
  • (-)-EBURNAMONINE 98+%
  • 3α,16α-Eburnamonine
  • EBURNAMONINE, (-)-(RG)
  • vinburnine
  • (-)-cis-Eburnamonine
  • Cervoxan
  • (41S,13aS)-13a-Ethyl-41-Methyl-2,3,5,6,13,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridin-12(41H)-one
  • EBURNAMONINE(VINBURNINE), (-)-(P)
  • (-)-Vi
  • (3α,16α)-14,15-Dihydroeburnamenin-14-one
  • 3a-Ethyl-2,3,3a,4,10,11b-hexahydro-1H,11H-5a,11a-diaza-benzo[cd]fluoranthen-5-one
  • EBURNAMONINE(VINBURNINE), (-)-(RG)
  • Vinburnine base
  • (3-alpha,16-alpha)-eburnamin-14(15h)-on
  • 3-alpha,16-alpha-eburnamonine
  • ch-846
  • cis-vincamone
  • eburnal
  • eburnalritardo
  • l-eburnamonine
  • (-)-Eburnamonine 4880-88-0
  • Vinpocetine Impurity 3 ((-)-Vincamone))
  • Vinpocetine Impurity 25
  • Eburnamenin-14(15H)-one, (3α,16α)-
  • High purity vinburnine
  • 4880-88-0
  • C19H22N2O
  • Cl9H22N20
  • Complex Molecules
  • Asymmetric Synthesis
  • Chiral Building Blocks
  • Inhibitors
  • Alkaloids
  • Complex Molecules
  • Asymmetric Synthesis
  • Chiral Building Blocks
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