Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30

Anti-ATG6,  Anti-BECN1,  Anti-Coiled-coil  myosin-like  BCL2-interacting  protein,  Anti-GT197,  Anti-VPS30 Struktur
CAS-Nr.
Englisch Name:
Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30
Synonyma:
Anti-ATG6;Anti-VPS30;Anti-GT197;Anti-BECN1;Anti-beclin1;Anti-ATG6 autophagy related 6 homolog;Anti-Beclin 1 antibody produced in rabbit;Anti-BECN1, (N-terminal) antibody produced in rabbit;Anti-Beclin 1 (N-terminal) antibody produced in rabbit;Anti-Beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
CBNumber:
CB92094705
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30 Eigenschaften

storage temp. 
-20°C
Aggregatzustand
buffered aqueous solution

Sicherheit

Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Anti-Beclin 1 (N-terminal) antibody produced in rabbit has been used in:
  • immunofluorescent staining
  • immunoblotting
  • immunohistochemistry
  • immunoprecipitation

Allgemeine Beschreibung

Beclin 1 (BECN1) or GT197 is a tumor suppressor gene. It is a Bcl-2 (B-cell lymphoma 2) interacting protein and is the mammalian ortholog of yeast Atg6/Vps30. It is a 450 amino-acid protein having three domains. The gene encoding BECN1 is localized on human chromosome 17q21.

Biochem/physiol Actions

Beclin 1 (BECN1) is able to complement the autophagy deficiency of yeast lacking autophagy-related gene 6 (Atg6) and restores autophagy in human MCF7 breast carcinoma cells. Beclin 1 plays a major role in the early development of embryo. It also serves as a haplo-insufficient tumor-suppressor gene. Heterozygous Beclin 1 mutant mice have increased spontaneous tumorigenesis. Beclin 1 is monoallelically deleted in a high percentage of sporadic human breast, ovarian and prostate carcinomas and is expressed at reduced levels in those tumors. In human brains BECN1 decreases in an age-dependent fashion, possibly leading to a reduction of autophagic activity during aging, which may contribute to the accumulation of mutant Huntingtin and the age-delayed disease onset of Huntington disease.

Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 16)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80

  • Anti-ATG6, Anti-BECN1, Anti-Coiled-coil myosin-like BCL2-interacting protein, Anti-GT197, Anti-VPS30
  • Anti-Beclin 1 (N-terminal) antibody produced in rabbit
  • Anti-Beclin 1 antibody produced in rabbit
  • Anti-beclin1
  • Anti-BECN1, (N-terminal) antibody produced in rabbit
  • Anti-ATG6 autophagy related 6 homolog
  • Anti-Beclin 1 (coiled-coil, moesin-like BCL2 interacting protein)
  • Anti-BECN1
  • Anti-GT197
  • Anti-VPS30
  • Anti-ATG6
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