Pyrrophenone

341973-06-6

CAS-Nr.: 341973-06-6

Englisch Name:: Pyrrophenone

Synonyma:: Pyrrophenone;N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide;Benzamide, N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[(triphenylmethyl)thio]-2-pyrrolidinyl]methyl]-4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-

CBNumber:: CB92592322

Summenformel:: C49H37F2N3O5S2

Molgewicht:: 849.962

MOL-Datei:: 341973-06-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 11

Pyrrophenone Eigenschaften

storage temp.: Store at -20°C

Löslichkeit: DMF: 12.5 mg/ml; DMSO: 15 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml

Aggregatzustand: A crystalline solid

Sicherheit

Pyrrophenone Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The group IVA phospholipase A₂ (PLA₂), known as calcium-dependent cytosolic PLA₂ (cPLA₂), selectively releases arachidonic acid (AA) from membrane phospholipids, playing a central role in initiating the synthesis of prostaglandins (PGs) and leukotrienes (LTs). Pyrrophenone inhibits cPLA₂α with an IC₅₀ of 4.2 nM in enzyme assays and potently blocks the release of AA and the production of PGE₂ and LTC₄ in cells (IC₅₀ = 24, 25, and 14 nM, respectively). Its action is reversible and selective, as pyrrophenone inhibits the secretory type IB and IIA PLA₂s with more than a hundred-fold less potency. Pyrrophenone has also been shown to inhibit calcium ionophore (A23187)-stimulated AA release from monocytic cells, interleukin-1-induced PGE₂ synthesis in mesangial cells, and the production of PGE₂, LTs, and platelet-activating factor by human neutrophils, always with maximal inhibition at concentrations below 1 μM.

Pyrrophenone Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pyrrophenone Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 11)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6870	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8141	58
Shanghai Universal Biotech Co.,Ltd	18768175414	gaojun@univ-bio.com	China	24998	58
Shanghai Tachizaki Biomedical Research Center	18014399201	sales@chemlab-tachizaki.com	China	2492	58
Nanjing Tengyi Biotechnology Co., Ltd	025-58851786 17714337195	sales@tybiochem.com	China	5141	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	8740	58
RD International Technology Co., Limited	18024082417	market@ubiochem.com	China	9180	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.com	China	24246	58

Pyrrophenone
N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-tritylsulfanylpyrrolidin-2-yl]methyl]-4-[(E)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]benzamide
Benzamide, N-[[(2S,4R)-1-[2-(2,4-difluorobenzoyl)benzoyl]-4-[(triphenylmethyl)thio]-2-pyrrolidinyl]methyl]-4-[(Z)-(2,4-dioxo-5-thiazolidinylidene)methyl]-
341973-06-6
C49H37F2N3O5S2