E3 ligase Ligand-Linker Conjugates 13

2010159-45-0

CAS-Nr.: 2010159-45-0

Englisch Name:: E3 ligase Ligand-Linker Conjugates 13

Synonyma:: VH032-PEG2-N3;S)-AHPC-PEG2-N3;(S,R,S)-AHPC-PEG2-azide;VHL Ligand-Linker Conjugates 6;E3 ligase Ligand-Linker Conjugates 13;E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3;(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate

CBNumber:: CB93386465

Summenformel:: C28H39N7O6S

Molgewicht:: 601.72

MOL-Datei:: 2010159-45-0.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 16

E3 ligase Ligand-Linker Conjugates 13 Eigenschaften

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Sicherheit

E3 ligase Ligand-Linker Conjugates 13 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Protein degrader builiding block (S,R,S)-AHPC-PEG2-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

E3 ligase Ligand-Linker Conjugates 13 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

E3 ligase Ligand-Linker Conjugates 13 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Xian confluore Biological Technology Co., Ltd.	+86-15680926068 +86-15680926068	1924344760@confluore.cn	China	2893	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9445	58
Xi'an Confluore Biological Technology Co., Ltd.	+86-156-80926068 +86-15680926068	1924344760@qq.com	China	4955	58
Jilin Province Woda Biotechnology Co., Ltd.	13504435624	1927928688@qq.com	China	1292	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Shanghai Kaiwei Chemical Technology Co., Ltd.	021-58461859 15821823057	service@aiviche.com	China	49323	58
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Shanghai Haohong Pharmaceutical Co., Ltd.	400-8210725 4008210725	malulu@leyan.com	China	39997	58

S)-AHPC-PEG2-N3
E3 ligase Ligand-Linker Conjugates 13
(S,R,S)-AHPC-PEG2-azide
VHL Ligand-Linker Conjugates 6
VH032-PEG2-N3
E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG2N3,Inhibitor,inhibit,(S,R,S)-AHPC-PEG-2-N3,(S,R,S) AHPC PEG2 N3
(2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
2010159-45-0