GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
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- CAS-Nr.
- Englisch Name:
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
- Synonyma:
- GDNF;RHGDNF;GDNF HUMAN;HUMAN GDNF;HUMAN ATF-1;REC GDNF (HUMAN);REC ATF-1 (HUMAN);RECOMBINANT HUMAN GDNF;Human GDNF Protein, Gly & Pro Tag;HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR
- CBNumber:
- CB9361171
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
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GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- lyophilized powder
- Farbe
- white
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Glial cell line-derived neurotrophic factor human (GDNF) has been used as a component in the neurobasal medium for neural differentiation. It has also been used for self-renewal, expansion and differentiation of?spermatogonial stem cells (SSCs).
Allgemeine Beschreibung
Glial cell line-derived neurotrophic factor (GDNF) human gene is located on human chromosome 5p13.2.
Biochem/physiol Actions
Glial Cell Line-Derived Neurotrophic Factor is a member of the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share ~93% sequence homology, with strong species cross-reactivity. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using the Parkinson′s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo.
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 77)Lieferanten
- HUMAN GDNF
- RECOMBINANT HUMAN GDNF
- HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR
- HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR
- HUMAN ATF-1
- GDNF
- GDNF (GLIAL DERIVED NEUROTROPIC FACTOR), HUMAN
- GDNF HUMAN
- GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR HUMAN
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN, RECOMBINANT
- GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN, RECOMBINANT, E COLI
- REC GDNF (HUMAN)
- REC GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (HUMAN)
- REC ASTROCYTE-DERIVED TROPHIC FACTOR 1 (HUMAN)
- REC ATF-1 (HUMAN)
- RHGDNF
- rec GDNF (huMan), rec Astrocyte-Derived Trophic Factor 1 (huMan), rec ATF-1 (huMan)
- Recombinant Human GDNF Protein, His & Fc Tag
- Recombinant Human GDNF Protein, His Tag
- Human GDNF Protein, Gly & Pro Tag
