GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN

CAS No.
Chemical Name:
GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN
Synonyms
GDNF;RHGDNF;GDNF HUMAN;HUMAN GDNF;HUMAN ATF-1;REC GDNF (HUMAN);REC ATF-1 (HUMAN);RECOMBINANT HUMAN GDNF;Human GDNF Protein, Gly & Pro Tag;HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR
CBNumber:
CB9361171
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00285867
MOL File:
Mol file
Last updated:2023-04-23 13:52:06

GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Properties

storage temp. -20°C
form lyophilized powder
color white

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P305+P351+P338
WGK Germany  3

GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SRP3309 GDNF human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) 10μG $448 2024-03-01 Buy
Sigma-Aldrich G1777 Glial Cell Line-derived Neurotrophic Factor human recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture, ≥98% (SDS-PAGE) 10μG $408 2024-03-01 Buy
Usbiological 383059 GDNF 96Tests $729 2021-12-16 Buy
Usbiological 383058 GDNF 96Tests $729 2021-12-16 Buy
Usbiological 383057 GDNF 96Tests $729 2021-12-16 Buy
Product number Packaging Price Buy
SRP3309 10μG $448 Buy
G1777 10μG $408 Buy
383059 96Tests $729 Buy
383058 96Tests $729 Buy
383057 96Tests $729 Buy

GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Chemical Properties,Uses,Production

Uses

Glial cell line-derived neurotrophic factor human (GDNF) has been used as a component in the neurobasal medium for neural differentiation. It has also been used for self-renewal, expansion and differentiation of?spermatogonial stem cells (SSCs).

General Description

Glial cell line-derived neurotrophic factor (GDNF) human gene is located on human chromosome 5p13.2.

Biochem/physiol Actions

Glial Cell Line-Derived Neurotrophic Factor is a member of the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share ~93% sequence homology, with strong species cross-reactivity. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using the Parkinson′s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development, including motoneurons, midbrain dopaminergic neurons, Purkinje cells and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo.

GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Preparation Products And Raw materials

Raw materials

Preparation Products

GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15421 60
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51471 80
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 4009686088 3193328036@qq.com China 29797 68
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973186 4009686088 3193328036@qq.com China 18352 68
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com meitaochem@126.com China 19105 58
Shanghai Kanglang Biotechnology Co., Ltd. 021-61998208 18217752821 sales@klbio.cn China 9617 58
Absin Bioscience Inc. 021-38015121 15000105423 chenjw@absin.cn China 24734 58
Wuhan Chemstan Biotechnology Co., Ltd. 15926423062 422450190@qq.com China 10132 58
Shanghai Universal Biotech Co.,Ltd 18768175414 gaojun@univ-bio.com China 24998 58
HUMAN GDNF RECOMBINANT HUMAN GDNF HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR HUMAN GLIAL-DERIVED NEUROTROPHIC FACTOR HUMAN ATF-1 GDNF GDNF (GLIAL DERIVED NEUROTROPIC FACTOR), HUMAN GDNF HUMAN GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN, RECOMBINANT GLIAL DERIVED NEUROTROPHIC FACTOR, HUMAN, RECOMBINANT, E COLI REC GDNF (HUMAN) REC GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (HUMAN) REC ASTROCYTE-DERIVED TROPHIC FACTOR 1 (HUMAN) REC ATF-1 (HUMAN) RHGDNF rec GDNF (huMan), rec Astrocyte-Derived Trophic Factor 1 (huMan), rec ATF-1 (huMan) Recombinant Human GDNF Protein, His & Fc Tag Recombinant Human GDNF Protein, His Tag Human GDNF Protein, Gly & Pro Tag