BRYOSTATIN 1
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- CAS-Nr.
- 83314-01-6
- Englisch Name:
- BRYOSTATIN 1
- Synonyma:
- BRYO 1;CS-1164;NSC-339555;BRYOSTATIN;Byrostatin 1;BRYOSTATIN 1;bryostatin1,0;(26R)-Bryostatin 1;Bryostatin 1 - CAS 83314-01-6 - Calbiochem;(1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
- CBNumber:
- CB9454936
- Summenformel:
- C47H68O17
- Molgewicht:
- 905.03
- MOL-Datei:
- 83314-01-6.mol
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BRYOSTATIN 1 Eigenschaften
- Schmelzpunkt:
- 230-235°
- alpha
- D25 +34.1° (c = 0.044 in methanol)
- Siedepunkt:
- 716.44°C (rough estimate)
- Dichte
- 1.1245 (rough estimate)
- Brechungsindex
- 1.5940 (estimate)
- storage temp.
- -20°C
- Löslichkeit
- DMSO: soluble
- pka
- 11.10±0.70(Predicted)
- Aggregatzustand
- solid
- Farbe
- white
- Optische Aktivität
- +34.125 (methanol)
Sicherheit
- Risiko- und Sicherheitserklärung
- Gefahreninformationscode (GHS)
| Kennzeichnung gefährlicher |
Xn |
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| R-Sätze: |
68 |
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| S-Sätze: |
22-24/25-36/37 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
EH9455000 |
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| HS Code |
2932990090 |
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| Toxizität |
LD50 in mice, rats (mg/kg): 0.038, 0.068 i.v. (Prendiville) |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizität (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| H373 |
Kann die Organe schädigen bei längerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizität (wiederholte Exposition) |
Kategorie 2 |
Warnung |
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P260, P314, P501 |
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| Sicherheit |
| P271 |
Nur im Freien oder in gut belüfteten Räumen verwenden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P312 |
Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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BRYOSTATIN 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Verwenden
Bryostatin 1 has been used to study its effects on spontaneous Crohn′s disease (CD) like colitis in?mice. It has also been used to study its effects as an anthelmintic drug on adult
Syphacia muris infection in rats.
Definition
ChEBI: A member of the class of bryostatins that is (17E)-2-oxooxacyclohexacos-17-ene which is substituted by hydroxy groups at positions 4, 10, and 20; an acetoxy group at position 8; methyl groups at positions 9, 9, 18, and 19; 2-methoxy-2-oxoe
hylidene groups at positions 14 and 24; an (E,E)-octa-2,4-dienoyloxy group at position 21; and with oxygen bridges linking positions 6 to 10, 12 to 16, and 20 to 24. It is one of the most abundant member of the class of br
ostatins.
Biologische Aktivität
Protein kinase C (PKC) activator that binds with high affinity (K i = 1.35 nM). Initially activates and subsequently induces downregulation of PKC isozymes. Sensitizes tumor cells to cytotoxic effects of anticancer agents.
BRYOSTATIN 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
BRYOSTATIN 1 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.
Global( 58)Lieferanten
83314-01-6()Verwandte Suche:
- BRYOSTATIN 1
- BRYO 1
- BRYOSTATIN
- bryostatin1,0
- (26R)-Bryostatin 1
- NSC-339555
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl2,4-octadienoicacidester
- 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-en
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-Methoxy-2-oxoethylidene)-10,10,26,26-tetraMethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-y
- Byrostatin 1
- CS-1164
- (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(Acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl-(2E, 4E)-2,4-octadienoic acid ester
- Bryostatin 1 - CAS 83314-01-6 - Calbiochem
- 2,4-Octadienoic acid, (1S,3S,5Z,7R,8E,11S,12S,13E,15S,17R,21R,23R,25S)-25-(acetyloxy)-1,11,21-trihydroxy-17-[(1R)-1-hydroxyethyl]-5,13-bis(2-methoxy-2-oxoethylidene)-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo[21.3.1.13,7.111,15]nonacos-8-en-12-yl ester, (2E,4E)-
- 83314-01-6
- C47H68O1
- C47H68O17
- Kinase/Phosphatase Biology
- Protein Kinase C (PKC)
- Serine/Threonine Kinase Activators
- Cell Signaling and Neuroscience
- Cell Biology
- BioChemical
- Cell Signaling and Neuroscience
- Kinase/Phosphatase Biology
- Protein Kinase ActivatorsSerine/Threonine Kinase Biology
- Protein Kinase C (PKC)
- Serine/Threonine Kinase Activators
- inhibitor
