BMS-763534

BMS-763534 Struktur
1188407-40-0
CAS-Nr.
1188407-40-0
Englisch Name:
BMS-763534
Synonyma:
BMS-763534;BMS-763534 >=98% (HPLC);2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-
CBNumber:
CB94669866
Summenformel:
C18H21ClF2N4O3
Molgewicht:
414.83
MOL-Datei:
1188407-40-0.mol

BMS-763534 Eigenschaften

Schmelzpunkt:
103.4-104.4 °C(Solv: heptane (142-82-5))
Siedepunkt:
470.4±55.0 °C(Predicted)
Dichte
1.45±0.1 g/cm3(Predicted)
storage temp. 
room temp
pka
1.89±0.40(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Optische Aktivität
[α]/D -40 to -55°, c = 0.8 in chloroform-d

Sicherheit

BMS-763534 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0.26 & 0.4 nM against 150 pM ovine CRF for binding rat & human CRF-R1, respectively), potency (IC50 = 1.0 nM against 0.3 nM CRF-stimulated ATCH secretion from primary rat anterior pituitary cells), and selectivity, displaying little affinity toward porcine CRF-R2/CRF2 and 46 other receptor/channel/transporter proteins (IC50 >10 μM). BMS-763534 inhibits CRF-stimulated cAMP production in human Y-79 retinoblastoma cells in cultures (pA2 = 9.47) and exhibits anxiolytic efficacy in a rat situational anxiety model in vivo (0.5-3 mg/kg p.o.).

BMS-763534 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


BMS-763534 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 3)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51471 80
Energy Chemical 021-58432009 400-005-6266
marketing1@energy-chemical.com China 44843 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 28070 58

  • BMS-763534
  • BMS-763534 >=98% (HPLC)
  • 2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-
  • 1188407-40-0
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