BMS-763534

BMS-763534 structure

CAS No.: 1188407-40-0

Chemical Name:: BMS-763534

Synonyms: BMS-763534;BMS-763534 >=98% (HPLC);2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]-

CBNumber:: CB94669866

Molecular Formula:: C18H21ClF2N4O3

Molecular Weight:: 414.83

MDL Number:: MFCD30718578

MOL File:: 1188407-40-0.mol

MSDS File:: SDS

Last updated:2023-04-23 13:52:06

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BMS-763534 Properties

Melting point	103.4-104.4 °C(Solv: heptane (142-82-5))
Boiling point	470.4±55.0 °C(Predicted)
Density	1.45±0.1 g/cm3(Predicted)
storage temp.	room temp
pka	1.89±0.40(Predicted)
form	powder
color	white to beige
optical activity	[α]/D -40 to -55°, c = 0.8 in chloroform-d

BMS-763534 price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	BM0031	BMS-763534 ≥98% (HPLC)	1188407-40-0	5MG	$95.7	2022-05-15	Buy
Sigma-Aldrich	BM0031	BMS-763534 ≥98% (HPLC)	1188407-40-0	25MG	$386	2022-05-15	Buy

Product number	Packaging	Price	Buy
BM0031	5MG	$95.7	Buy
BM0031	25MG	$386	Buy

BMS-763534 Chemical Properties,Uses,Production

Biochem/physiol Actions

BMS-763534 is a pyrazinone-containing antagonist that targets corticotropin-releasing factor/hormone (CRF or CRH) receptor 1 (CRF1, CRF-R1, CRFR-1, CRH-R1, CRHR-1) with high affinity (IC50 = 0.26 & 0.4 nM against 150 pM ovine CRF for binding rat & human CRF-R1, respectively), potency (IC50 = 1.0 nM against 0.3 nM CRF-stimulated ATCH secretion from primary rat anterior pituitary cells), and selectivity, displaying little affinity toward porcine CRF-R2/CRF2 and 46 other receptor/channel/transporter proteins (IC50 >10 μM). BMS-763534 inhibits CRF-stimulated cAMP production in human Y-79 retinoblastoma cells in cultures (pA2 = 9.47) and exhibits anxiolytic efficacy in a rat situational anxiety model in vivo (0.5-3 mg/kg p.o.).

BMS-763534 Preparation Products And Raw materials

Raw materials

Preparation Products

BMS-763534 Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80
Energy Chemical	021-58432009 400-005-6266	marketing1@energy-chemical.com	China	44843	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	16377	58

Supplier	Advantage
Sigma-Aldrich	80
Energy Chemical	58
TargetMol Chemicals Inc.	58

BMS-763534 BMS-763534 >=98% (HPLC) 2(1H)-Pyrazinone, 5-chloro-1-[(1S)-1-cyclopropyl-2-methoxyethyl]-3-[[6-(difluoromethoxy)-2,5-dimethyl-3-pyridinyl]amino]- 1188407-40-0