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1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- structure

CAS No.: 2284460-01-9

Chemical Name:: 1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-

Synonyms: MC2590;1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-

CBNumber:: CB012900345

Molecular Formula:: C20H17N3O3

Molecular Weight:: 347.37

MDL Number:

MOL File:: 2284460-01-9.mol

Last updated:2025-11-10 14:44:25

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1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Properties

Density	1.362±0.06 g/cm3(Predicted)
pka	8.63±0.23(Predicted)

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Chemical Properties,Uses,Production

Uses

MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor. MC2590 is a inhibitor of HDAC1-3, -6, -8, and -10 (class I/IIb-selective inhibitor) with IC50s of 0.015 μM-0.156 μM. MC2590 also inhibits HDAC isoforms HDAC4, HDAC5, HDAC7, HDAC9, HDAC11 with IC50s of 1.35 μM-3.98 μM. MC2625 induces G2/M cell cycle arrest and modulates pro- and anti-apoptotic microRNAs towards apoptosis induction[1].

IC 50

HDAC1: 0.098 μM (IC₅₀); HDAC2: 0.156 μM (IC₅₀); HDAC3: 0.039 μM (IC₅₀); HDAC6: 0.015 μM (IC₅₀); HDAC8: 0.047 μM (IC₅₀); HDAC10: 0.071 μM (IC₅₀); HDAC4: 2.73 μM (IC₅₀); HDAC5: 1.35 μM (IC₅₀); HDAC7: 2.06 μM (IC₅₀); HDAC9: 2.79 μM (IC₅₀); HDAC11: 3.98 μM (IC₅₀)

References

[1] Elisabetta Di Bello, et al. Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells. Eur J Med Chem. 2022 Dec 15;247:115022. DOI:10.1016/j.ejmech.2022.115022

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Suppliers

Global( 6)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32435	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	4782	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11973	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	29641	58
Sangon Biotech (Shanghai) Co.,Ltd.	400-821-026	Sales@sangon.com	China	6710	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
Sangon Biotech (Shanghai) Co.,Ltd.	58

View Lastest Price from 1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-11-09	MC2590 2284460-01-9	US $1570.00-347.00 / mg		99.64%	10g	TargetMol Chemicals Inc.

MC2590
2284460-01-9
US $1570.00-347.00 / mg
99.64%
TargetMol Chemicals Inc.

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- Spectrum

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]-(2284460-01-9)¹HNMR

1-Naphthaleneacetamide, N-[6-[3-(hydroxyamino)-3-oxo-1-propen-1-yl]-3-pyridinyl]- MC2590 2284460-01-9