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ChemicalBook >> CAS DataBase List >>2'-cyano-2'-deoxyarabinofuranosylcytosine

2'-cyano-2'-deoxyarabinofuranosylcytosine

2'-cyano-2'-deoxyarabinofuranosylcytosine Structure
2'-cyano-2'-deoxyarabinofuranosylcytosine structure
CAS No.
134665-72-8
Chemical Name:
2'-cyano-2'-deoxyarabinofuranosylcytosine
Synonyms
TAS109;TAS 109;CNDAC HCl;CNDAC HCl salt;CNDAC hydrochloride;TAS-109 Hydrochloride;DFP-10917 Hydrochloride;CNDAC hydrochloride, 10 mM in DMSO;2'-cyano-2'-deoxyarabinofuranosylcytosine;2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride
CBNumber:
CB01322158
Molecular Formula:
C10H12N4O4.ClH
Molecular Weight:
288.69
MDL Number:
MOL File:
134665-72-8.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-18 07:23:31
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2'-cyano-2'-deoxyarabinofuranosylcytosine Properties

storage temp. Store at -20°C
solubility DMSO: 125 mg/mL (432.99 mM)
form Solid
color White to off-white
FDA UNII VSS4ZDZ2IE

2'-cyano-2'-deoxyarabinofuranosylcytosine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 40672 CNDAC (hydrochloride) ≥98% 134665-72-8 5mg $98 2026-04-30 Buy
Cayman Chemical 40672 CNDAC (hydrochloride) ≥98% 134665-72-8 10mg $186 2026-04-30 Buy
Cayman Chemical 40672 CNDAC (hydrochloride) ≥98% 134665-72-8 25mg $368 2026-04-30 Buy
Cayman Chemical 40672 CNDAC (hydrochloride) ≥98% 134665-72-8 50mg $637 2026-04-30 Buy
Biosynth JFA66572 Cndac hydrochloride 134665-72-8 10mg $1075.9 2026-06-04 Buy
Product number Packaging Price Buy
40672 5mg $98 Buy
40672 10mg $186 Buy
40672 25mg $368 Buy
40672 50mg $637 Buy
JFA66572 10mg $1075.9 Buy

2'-cyano-2'-deoxyarabinofuranosylcytosine Chemical Properties, Uses, Production

Uses

CNDAC hydrochloride is a metabolite of the orally active agent Sapacitabine (HY-16445), and a nucleoside analog. CNDAC hydrochloride induces DNA damage and apoptosis[1][2].

in vivo

CNDAC (20mg/kg; i.p.; daily for 10 days) shows antitumor activity in mice[4].

Animal Model:CDF1 mice, P388 tumor model[4]
Dosage:20 mg/kg
Administration:Intraperitoneal injection, daily for 10 days
Result:Greatly increased the survival time and survival rate.

References

[1] Liu XJ, et al. Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks. Chin J Cancer. 2012 Aug;31(8):373-80. DOI:10.5732/cjc.012.10077
[2] Jagan S, et al. Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine. Adv Hematol. 2012;2012:727683. DOI:10.1155/2012/727683
[3] Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36. DOI:10.1038/sj.bjc.6603896
[4] Azuma A, et al. Nucleosides and nucleotides. 122. 2'-C-cyano-2'-deoxy-1-beta-D-arabinofuranosylcytosine and its derivatives. A new class of nucleoside with a broad antitumor spectrum. J Med Chem. 1993 Dec 24;36(26):4183-9. DOI:10.1021/jm00078a006

2'-cyano-2'-deoxyarabinofuranosylcytosine Preparation Products And Raw materials

Raw materials

Preparation Products

2'-cyano-2'-deoxyarabinofuranosylcytosine Suppliers

Global Suppliers ( 43)
Supplier Tel Email Country ProdList Advantage
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2915 55
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070 13770331960 info@chemlin.com.cn China 16307 64
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618 sales@adobechem.com China 1250 50
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 87240 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 7996 62
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9765 58
Medi-tech Bioscientific Co., Ltd. 0519-83246372 13585352506 China 1838 58
Chemleader Biomedical Co., Limited. 021-58180488 sales@MedChemLeader.com China 1004 58
Shanghai Biopharmaleader Co., Ltd. +86 18721201413 sales@biopharmaleader.com China 1711 58
Supplier Advantage
Shanghai Boyle Chemical Co., Ltd. 55
Chembest Research Laboratories Limited 61
Nanjing Chemlin Chemical Co., Ltd 64
Shanghai YuanQi Biotechnology Co., Ltd. 50
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Chaolan Chemical Technology Center 58
Medi-tech Bioscientific Co., Ltd. 58
Chemleader Biomedical Co., Limited. 58
Shanghai Biopharmaleader Co., Ltd. 58

View Latest Price from 2'-cyano-2'-deoxyarabinofuranosylcytosine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CNDAC hydrochloride pictures 2026-07-17 CNDAC hydrochloride
134665-72-8
 $116.00-448.00 99.45% 10g TargetMol Chemicals Inc.
CNDAC hydrochloride pictures 2026-07-17 CNDAC hydrochloride
134665-72-8
 $116.00-448.00 99.45% 10g TargetMol Chemicals Inc.

2'-cyano-2'-deoxyarabinofuranosylcytosine Spectrum

2'-cyano-2'-deoxyarabinofuranosylcytosine(134665-72-8)1HNMR

134665-72-8 (2'-cyano-2'-deoxyarabinofuranosylcytosine) Related Search:

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Bendamustine-d4 (hydrochloride)

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2'-cyano-2'-deoxyarabinofuranosylcytosine CNDAC HCl salt 2'-Cyano-2'-deoxyarabinofuranosylcytosine hydrochloride 1-(2-C-cyano-2-deoxy-β-D-arabinofuranosyl)cytosine hydrochloride TAS-109 Hydrochloride TAS109 TAS 109 DFP-10917 HYDROCHLORIDE; TAS-109 HYDROCHLORIDE;CNDAC;TAS109;TAS 109 DFP-10917 Hydrochloride CNDAC HCl (2R,3S,4S,5R)-2-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-3-carbonitrile hydrochloride CNDAC hydrochloride inhibit,Drug Metabolite,CNDAC hydrochloride,Inhibitor,CNDAC,Nucleoside Antimetabolite/Analog CNDAC hydrochloride, 10 mM in DMSO 134665-72-8