BL7040)
- CAS No.
- 864021-55-6
- Chemical Name:
- BL7040)
- Synonyms
- BL7040);ODN7040;Monarsen(Synonyms:EN101
- CBNumber:
- CB013383992
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| Sequence | DNA, d(C-T-G-C-G-A-T-A-T-T-T-T-C-T-T-G-T-rAm-rCm-rCm) |
|---|---|
| FDA UNII | 4TT3V55XYT |
BL7040) Chemical Properties,Uses,Production
Uses
Monarsen (EN101) is a synthetic 20-base antisense oligodeoxynucleotide directed against the human AChE gene. Monarsen is used in the study of Autoimmune myasthenia gravis (MG), a neuromuscular disorder caused by autoantibodies directed against the acetylcholine receptor (AChR).
IC 50
AChE
References
[1] Sussman JD, Argov Z, McKee D, Hazum E, Brawer S, Soreq H. Antisense treatment for myasthenia gravis: experience with monarsen. Ann N Y Acad Sci. 2008;1132:283-290. DOI:10.1196/annals.1405.022
[2] Evron T, Moyal-Segal LB, Lamm N, Geffen A, Soreq H. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegener Dis. 2005;2(1):16-27. DOI:10.1159/000086427
[3] Kehat R, Zemel E, Cuenca N, et al. A novel isoform of acetylcholinesterase exacerbates photoreceptors death after photic stress. Invest Ophthalmol Vis Sci. 2007;48(3):1290-1297. DOI:10.1167/iovs.06-0847
BL7040) Preparation Products And Raw materials
Raw materials
Preparation Products
BL7040) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai meikai technology co., ltd | 021-68689288 15300790979 | info@mkbio.com.cn | China | 5000 | 58 |
| Supplier | Advantage |
|---|---|
| Shanghai meikai technology co., ltd | 58 |
