2'',3'',5''-Triacetyl -azacytidine
- CAS No.
- 10302-78-0
- Chemical Name:
- 2'',3'',5''-Triacetyl -azacytidine
- Synonyms
- Nsc291930;-O-triacetate;Triacetyl azacitidine;Azacitidine Triacetate;Azacitidine Impurity 48;Intermediate of Azacitidine;2'3'5'-triacetyl-5-Azacytosine;2',3',5'-triacetyl-5-Azacytidine;2',3',5'-Tri-O-Acetyl-Azacytidine;2'',3'',5''-Triacetyl -azacytidine
- CBNumber:
- CB01564248
- Molecular Formula:
- C14H18N4O8
- Molecular Weight:
- 370.31
- MDL Number:
- MFCD11113159
- MOL File:
- 10302-78-0.mol
Boiling point | 497.3±55.0 °C(Predicted) |
---|---|
Density | 1.60±0.1 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
form | crystalline solid |
pka | 3.06±0.20(Predicted) |
CAS DataBase Reference | 10302-78-0 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
2'',3'',5''-Triacetyl -azacytidine price More Price(21)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 13373 | 2',3',5'-triacetyl-5-Azacytidine ≥95% | 10302-78-0 | 5mg | $62 | 2024-03-01 | Buy |
Cayman Chemical | 13373 | 2',3',5'-triacetyl-5-Azacytidine ≥95% | 10302-78-0 | 10mg | $115 | 2024-03-01 | Buy |
Cayman Chemical | 13373 | 2',3',5'-triacetyl-5-Azacytidine ≥95% | 10302-78-0 | 50mg | $477 | 2024-03-01 | Buy |
Cayman Chemical | 13373 | 2',3',5'-triacetyl-5-Azacytidine ≥95% | 10302-78-0 | 100mg | $834 | 2024-03-01 | Buy |
TRC | A796030 | 5-Azacytidine2’,3’5’-O-triacetate | 10302-78-0 | 50mg | $265 | 2021-12-16 | Buy |
2'',3'',5''-Triacetyl -azacytidine Chemical Properties,Uses,Production
Description
5-
Chemical Properties
White to off-white powder
Uses
5-Azacytidine is an inhibitor of DNA methyltransferaes, potentially serving to reverse epigenetic changes. It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes and cancer. 2’,3’,5’-triacetyl-5-Azacytidine is a prodrug form of 5-azacytidine that may be rapidly absorbed orally without formation of major metabolites in the gastrointestinal tract.[Cayman Chemical]
in vivo
in cd-1 mice, oral administration of tac for five days per week for 2 weeks didn’t result in animal deaths and weight loss, but induced changes in hematological parameters, lymph nodes, bone marrow, and duodenal epithelium. tac inhibited global dna methylation in the spleen and gut. in an in vivo l1210 leukemia model, tac exhibited antineoplastic activity [1].
References
[1] ziemba a, ramirez m c, freeman b, et al. abstract# 3369: development of oral demethylating agents for the treatment of myelodysplastic syndrome[j]. 2009.
[2] brueckner b, boy r g, siedlecki p, et al. epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human dna methyltransferases[j]. cancer research, 2005, 65(14): 6305-6311.
2'',3'',5''-Triacetyl -azacytidine Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 18214 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9341 | 55 |
Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34571 | 58 |
HONG KONG IPURE BIOLOGY CO.,LIMITED | 86 18062405514 18062405514 | ada@ipurechemical.com | CHINA | 3465 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
View Lastest Price from 2'',3'',5''-Triacetyl -azacytidine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-29 | 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
|
US $10.00-3.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | ||
2022-09-27 | 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
- 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
- US $10.00-3.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
- 2'',3'',5''-Triacetyl -azacytidine
10302-78-0
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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