C5-DEPLETED SERUM, HUMAN
- CAS No.
- Chemical Name:
- C5-DEPLETED SERUM, HUMAN
- Synonyms
- C5-DEPLETED SERUM, HUMAN;COMPLEMENT C5-DEPLETED SERUM, HUMAN;COMPLEMENT C5 DEFICIENT SERUM HUMAN
- CBNumber:
- CB0202734
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00130841
- MOL File:
- Mol file
SAFETY
Risk and Safety Statements
| Hazard Codes | B |
|---|---|
| WGK Germany | 3 |
| Storage Class | 12 - Non Combustible Liquids |
C5-DEPLETED SERUM, HUMAN price More Price(1)
C5-DEPLETED SERUM, HUMAN Chemical Properties, Uses, Production
Uses
Complement C5 deficiencies in humans are rare, but often associated with recurrent infections by Neisseria spp. (such as meningitis). Deficiency in C5 results in an impairment of hemolytic activity from both the classical and alternative pathway of the complement system. Recently, genetic research has revealed that a 153 bp deletion in exon 30 results in complete C5 deficiency. Research has also implicated C5 deficiency in a predisposition to cardiac dysfunction when cardiac injury occurs.
Biochem/physiol Actions
Complement C5 deficiency can, paradoxically, protect against certain effects of infection. Patients deficient in C5 are unusually susceptible to meningococcal infection, but have a milder course of infection. Reduced expression of tumor necrosis factor (TNF) may account for this effect.
C5-DEPLETED SERUM, HUMAN Preparation Products And Raw materials
Raw materials
Preparation Products
C5-DEPLETED SERUM, HUMAN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Merck Millipore | -- | bioscience@merckgroup.com | China | 6833 | 58 |
| Merck KGaA | -- | ordercn@merckgroup.com | China | 6376 | 58 |
| Riedel-de Haen AG | -- | United States | 6624 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6825 | 91 | |
| Kanto Chemical Co., Inc. | -- | reag-info@gms.kanto.co.jp | Japan | 6739 | 74 |
| EMD Biosciences, Inc. | -- | technical@calbiochem.com | United States | 6527 | 66 |
| VWR International | -- | solutions@vwr.com | United Kingdom | 6523 | 82 |
| Supplier | Advantage |
|---|---|
| Merck Millipore | 58 |
| Merck KGaA | 58 |
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| Kanto Chemical Co., Inc. | 74 |
| EMD Biosciences, Inc. | 66 |
| VWR International | 82 |
